Joshi H N, Wilson T D
Bristol-Myers Squibb, New Brunswick, NJ 08903-0191, USA.
J Pharm Pharmacol. 1995 Mar;47(3):188-92. doi: 10.1111/j.2042-7158.1995.tb05776.x.
We have investigated the mechanism of hydration of cholestyramine, a water-insoluble resin used pharmaceutically. Two types of water of hydration (freezing and non-freezing) and the amounts of heat evolved or absorbed during the hydration of cholestyramine were determined. From differential scanning calorimetry, 0.57 g water was observed to be tightly bound per gram of resin (non-freezing water). The hydration of dry cholestyramine was found to be exothermic. The heats of hydration of cholestyramine with chloride or nitrate counter-anions were found to be -6.05 and -3.46 cal g-1, respectively. Some of the partially hydrated cholestyramine samples showed absorption of heat during hydration. The data generated in the study were utilized to better understand the mechanism of hydration and swelling of cholestyramine.
我们研究了消胆胺（一种药学上使用的水不溶性树脂）的水合作用机制。测定了两种水合水（冷冻水和非冷冻水）以及消胆胺水合过程中放出或吸收的热量。通过差示扫描量热法观察到，每克树脂紧密结合0.57克水（非冷冻水）。发现干燥的消胆胺水合是放热的。消胆胺与氯离子或硝酸根离子抗衡阴离子的水合热分别为-6.05和-3.46 cal g-1。一些部分水合的消胆胺样品在水合过程中显示出吸热。该研究中产生的数据用于更好地理解消胆胺的水合和溶胀机制。
