Horswill C A, Kien L, Zipf W B, McCoy K S
Department of Pediatrics, Ohio State University College of Medicine, Columbus, USA.
JPEN J Parenter Enteral Nutr. 1994 Nov-Dec;18(6):497-502. doi: 10.1177/0148607194018006497.
Seven children with cystic fibrosis (aged 7 to 12 years) were studied in the fasted and fed states. Using a primed, constant, intravenous infusion of NaH13CO3, the rate of appearance of CO2 (RaCO2) was estimated. Net CO2 excretion (VCO2) was also measured. Energy expenditure was calculated using the food quotient. RaCO2 (mean +/- SD) (mumol.kg-1.min-1) in the fasted and fed states (297 +/- 59 and 359 +/- 67) was 117% and 105% of VCO2 (259 +/- 48 and 352 +/- 72). Feeding induced a 23% and a 37% increase in RaCO2 and VCO2, respectively, and respective 19% and 33% increases in energy expenditure (p < .05). Measurement of CO2 production by isotopic dilution is a useful index of group changes in energy expenditure, including those induced by feeding.
对7名囊性纤维化患儿（年龄7至12岁）在空腹和进食状态下进行了研究。通过静脉注射NaH13CO3并进行初始定量持续输注，估算了二氧化碳生成速率（RaCO2）。同时也测量了净二氧化碳排出量（VCO2）。利用食物商数计算能量消耗。空腹和进食状态下的RaCO2（平均值±标准差）（μmol·kg-1·min-1）分别为（297±59和359±67），分别是VCO2（259±48和352±72）的117%和105%。进食分别使RaCO2和VCO2增加了23%和37%，能量消耗分别增加了19%和33%（p<.05）。通过同位素稀释法测量二氧化碳生成量是能量消耗群体变化的一个有用指标，包括进食引起的变化。
