Taguchi O, Hida W, Kikuchi Y, Miki H, Iijima H, Homma M, Tamura G, Shirato K
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Dec;32 Suppl:115-20.
In the first study, we used pulse oximetry to continuously measure SpO2 and pulse rate in inpatients with paroxysmal attacks of acute asthma. Desaturation and increases in pulse rate occurred during coughing, urination, defecation, eating, and sleeping. Desaturation was most severe and frequent when peak expiratory flow was in the red zone. When it was in the yellow zone or blue zone, desaturation was less severe and less frequent. In the second study, outpatients experiencing exacerbations of chronic asthma and inpatients experiencing acute asthmatic attacks inhaled of a beta 2-stimulant via an ultrasonic nebulizer and were monitored with pulse oximetry. In the former, SpO2 either did not change or increased, but in the latter SpO2 decreased markedly when patients were in the red zone. Therefore, when patients inhale a bronchodilator during an acute asthmatic attack they should be carefully monitored with pulse oximetry. In the third study, pulse oximetry was used to measure saturation in outpatients who were suspected of having hyperresponsive airways and had undergone an airway hyperresponsiveness test with an Astograph. Almost all of those who had desaturation of more than 4% from were markedly hyperresponsive. The degree of desaturation and the percent change in respiratory resistance were significantly correlated. In conclusion, pulse oximetry can be useful in the short-term and long-term management of asthma tic patients.
在第一项研究中，我们使用脉搏血氧饱和度仪连续测量急性哮喘阵发性发作住院患者的SpO₂和脉搏率。咳嗽、排尿、排便、进食和睡眠期间出现血氧饱和度下降和脉搏率增加。当呼气峰值流速处于红色区域时，血氧饱和度下降最为严重且频繁。当处于黄色区域或蓝色区域时，血氧饱和度下降程度较轻且频率较低。在第二项研究中，慢性哮喘急性加重的门诊患者和急性哮喘发作的住院患者通过超声雾化器吸入β₂-激动剂，并使用脉搏血氧饱和度仪进行监测。在前者中，SpO₂要么没有变化，要么升高，但在后者中，当患者处于红色区域时，SpO₂明显下降。因此，当患者在急性哮喘发作期间吸入支气管扩张剂时，应使用脉搏血氧饱和度仪进行仔细监测。在第三项研究中，脉搏血氧饱和度仪用于测量疑似气道高反应性且已使用Astograph进行气道高反应性测试的门诊患者的血氧饱和度。几乎所有血氧饱和度下降超过4%的患者都有明显的高反应性。血氧饱和度下降程度与呼吸阻力变化百分比显著相关。总之，脉搏血氧饱和度仪在哮喘患者的短期和长期管理中可能有用。
