Langeland M, Lingaas F
Department of Small Animal Clinical Sciences, Norwegian College of Veterinary Medicine, Oslo.
J Small Anim Pract. 1995 Apr;36(4):166-9. doi: 10.1111/j.1748-5827.1995.tb02872.x.
This study presents the estimates of heritability for spondylosis deformans in the boxer based on 353 offspring from 24 randomly selected sires, each with at least three radiographically investigated offspring. The estimated heritability (h2) for maximum degree of osteophyte development was high, both when estimated by paternal half-sib correlation (0.42) and by the regression of offspring based on the parents (0.62). The heritability for the number of affected discs estimated by paternal half-sib correlation was also high (0.47). The estimate of heritability for the number of affected discs based on regression of offspring on the parents was lower at 0.13. All heritabilities had large standard errors. A positive phenotypic correlation between spondylosis deformans and hip dysplasia was observed. Assuming a significant portion of the correlation is genetic, this fact may permit selection against spondylosis deformans without negatively influencing the incidence of hip dysplasia. Since the incidence of spondylosis deformans is high even in young dogs, it should be possible to detect a large proportion of genetically predisposed animals by radiographic examination of the spine at one year of age; at the same time that dogs are presented for a routine test for hip dysplasia.
本研究基于24只随机挑选的种公犬的353只后代，对拳师犬脊柱关节病的遗传力进行了估计，每只种公犬至少有三只接受过X光检查的后代。通过父系半同胞相关性估计的骨赘发育最大程度的遗传力（h2）很高，通过后代基于父母的回归分析估计的遗传力也很高（0.62）。通过父系半同胞相关性估计的受影响椎间盘数量的遗传力也很高（0.47）。基于后代对父母的回归分析，受影响椎间盘数量的遗传力估计值较低，为0.13。所有遗传力的标准误差都很大。观察到脊柱关节病与髋关节发育不良之间存在正表型相关性。假设这种相关性的很大一部分是遗传的，这一事实可能允许在不负面影响髋关节发育不良发病率的情况下，对脊柱关节病进行选择淘汰。由于即使在幼犬中脊柱关节病的发病率也很高，因此通过在一岁时对脊柱进行X光检查，应该有可能检测出很大一部分具有遗传易感性的动物；与此同时，犬只也会接受髋关节发育不良的常规检测。
