Szczepański M, Habior A, Szczepanik A, Soszka A, Grel K
Dept. of Biochemistry, Medical Center of Postgraduate Education, Warsaw, Poland.
Mater Med Pol. 1994 Jul-Sep;26(3):87-90.
The thrombin clotting time and the fibrin polymerization test were performed in 64 patients with liver cirrhosis. Each test was made with thrombin diluted with 150 mmol/l sodium chloride and 25 mmol/l calcium chloride. The thrombin-in-NaCl clotting time was found to be prolonged in 39% of cirrhotic patients, whereas fibrin polymerization was defective in 65% of them. Dilution of thrombin with calcium chloride diminished the number of abnormal results of both tests in patients with liver cirrhosis. Among the performed tests most sensitive test proved to be the polymerization of fibrin induced by thrombin diluted with sodium chloride.
对64例肝硬化患者进行了凝血酶凝血时间和纤维蛋白聚合试验。每项试验均使用用150 mmol/L氯化钠和25 mmol/L氯化钙稀释的凝血酶进行。发现39%的肝硬化患者凝血酶在氯化钠中的凝血时间延长，而65%的患者纤维蛋白聚合存在缺陷。用氯化钙稀释凝血酶可减少肝硬化患者两项试验的异常结果数量。在所进行的试验中，最敏感的试验被证明是用氯化钠稀释的凝血酶诱导的纤维蛋白聚合。
