Macleod R J, Bennett H P, Hamilton J R
McGill University-Montreal Children's Hospital Research Institute.
Lancet. 1995 Jul 8;346(8967):90-2. doi: 10.1016/s0140-6736(95)92115-x.
Rates of stool output are reduced when cooked rice is incorporated into oral rehydration solutions. We found that a fraction extracted from rice inhibited the response of intestinal epithelial crypt cells to adenosine 3'5'-cyclic monophosphate, a major intracellular mediator of secretion. This response to rice was seen as an inhibition of cell shrinkage and of chloride efflux in fresh suspended guinea pig crypt cells. The active fraction was of low molecular weight (< 1.5 kDa), hydrophobic, and not a peptide or glycoprotein. It may be chloride-channel blocker.
当将煮熟的米饭加入口服补液溶液中时，粪便排出率会降低。我们发现从大米中提取的一种成分可抑制肠上皮隐窝细胞对3',5'-环磷酸腺苷（一种主要的细胞内分泌介质）的反应。在新鲜悬浮的豚鼠隐窝细胞中，这种对大米的反应表现为对细胞收缩和氯离子外流的抑制。活性成分分子量低（<1.5 kDa），具有疏水性，不是肽或糖蛋白。它可能是一种氯离子通道阻滞剂。
