基于低渗葡萄糖和大米的口服补液盐溶液治疗成人霍乱的疗效。
Efficacy of oral hyposmolar glucose-based and rice-based oral rehydration salt solutions in the treatment of cholera in adults.
作者信息
Bhattacharya M K, Bhattacharya S K, Dutta D, Deb A K, Deb M, Dutta A, Saha Choudhury A, Nair G B, Mahalanabis D
机构信息
National Institute of Cholera and Enteric Diseases, Calcutta, India.
出版信息
Scand J Gastroenterol. 1998 Feb;33(2):159-63. doi: 10.1080/00365529850166888.
BACKGROUND
Recent animal experiments and clinical trials have shown that both osmolarity and rice as the organic components are important factors for net intestinal absorption of an oral rehydration salt solution.
METHODS
In a controlled clinical trial 123 male adult patients with severe cholera, after initial rehydration with intravenous Ringer's lactate solution, were randomly assigned to receive one of the four oral rehydration salt solutions: WHO ORS, ORS containing 70 mmol/l Na+ and 16.2 g/l glucose, rice ORS containing 50 g/l rice and 90 mmol/l Na+, and rice ORS containing 50 g/l rice and 70 mmol/l Na+. All patients received 300 mg of doxycycline as a single dose.
RESULTS
Patients who received rice-low-sodium ORS subsequently had lower (P < 0.05) stool output, ORS consumption, and diarrhoea duration than the other three ORS groups.
CONCLUSIONS
We conclude that rice-based low-sodium ORS is superior for treating adult cholera.
背景
近期的动物实验和临床试验表明，渗透压以及作为有机成分的大米都是口服补液盐溶液肠道净吸收的重要因素。
方法
在一项对照临床试验中，123名成年男性重症霍乱患者在先用静脉注射乳酸林格氏液进行初始补液后，被随机分配接受四种口服补液盐溶液之一：世界卫生组织口服补液盐（WHO ORS）、含70 mmol/L钠和16.2 g/L葡萄糖的口服补液盐、含50 g/L大米和90 mmol/L钠的大米口服补液盐，以及含50 g/L大米和70 mmol/L钠的大米口服补液盐。所有患者均单次服用300 mg强力霉素。
结果
与其他三组口服补液盐组相比，接受低钠大米口服补液盐的患者随后的粪便排出量、口服补液盐消耗量和腹泻持续时间更低（P < 0.05）。
结论
我们得出结论，低钠大米口服补液盐在治疗成人霍乱方面更具优势。
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