Darke S G, Ross J E, Hall W D
National Drug and Alcohol Research Centre, University of New South Wales.
Med J Aust. 1995 Jun 19;162(12):645-7. doi: 10.5694/j.1326-5377.1995.tb126051.x.
To determine the extent and patterns of benzodiazepine use among heroin users, and whether preferences for different benzodiazepines exist among this group.
210 heroin users who were current users of benzodiazepines volunteered for the study and completed a structured questionnaire.
Heroin users had used a median of five different benzodiazepines, most commonly diazepam. Almost half the subjects (48%; 95% CI, 41-55) had injected benzodiazepines, 17% (95% CI, 12-22) within the preceding six months. Diazepam and temazepam were the most widely injected benzodiazepines.
Flunitrazepam, diazepam and temazepam should be prescribed to heroin users with caution. A less popular and rarely injected benzodiazepine, nitrazepam, may be a better option for this group.
确定海洛因使用者中苯二氮䓬类药物的使用程度和模式，以及该群体对不同苯二氮䓬类药物是否存在偏好。
210名目前正在使用苯二氮䓬类药物的海洛因使用者自愿参与该研究，并完成了一份结构化问卷。
海洛因使用者使用过的苯二氮䓬类药物中位数为五种，最常用的是地西泮。近一半的受试者（48%；95%置信区间，41 - 55）曾注射过苯二氮䓬类药物，其中17%（9�%置信区间，12 - 22）在过去六个月内有过注射行为。地西泮和替马西泮是注射最为广泛的苯二氮䓬类药物。
应谨慎为海洛因使用者开具氟硝西泮、地西泮和替马西泮。一种较不常用且很少被注射的苯二氮䓬类药物硝西泮，可能对该群体是更好的选择。
