Lichter I, Hunt E
N Z Med J. 1995 Jun 14;108(1001):224-6.
Because of widely differing views on the drugs that can be administered in combination, this study was undertaken to record the combination of drugs in syringe drivers that we had found to be compatible.
The content of syringe drivers in 100 consecutive patients in whom continuous subcutaneous infusion was used, was recorded. The incidence of skin reactions with the different drugs was noted. The efficacy of combinations used was assessed clinically.
A wide variety of drugs were used in many different combinations, with no clinical evidence of loss of efficacy. Some drug combinations are incompatible. Drugs known to cause skin reactions were not administered. In this study skin reactions depended on the number of drugs used in combination.
The array of medications that can be used together in syringe drivers enable this method of drug administration to be used successfully in the control of the diverse symptoms that may arise in terminal illness. Further study is needed for quantitative measurement of drug stability.
由于对于可联合使用药物的观点存在广泛差异，开展本研究以记录我们发现可相容于皮下注射泵的药物组合。
记录连续100例使用持续皮下输注患者皮下注射泵中的药物内容物。记录不同药物的皮肤反应发生率。临床评估联合用药的疗效。
多种药物以许多不同组合使用，无疗效丧失的临床证据。一些药物组合不相容。未使用已知会引起皮肤反应的药物。在本研究中，皮肤反应取决于联合使用的药物数量。
皮下注射泵中可一起使用的一系列药物使这种给药方法能够成功用于控制终末期疾病可能出现的各种症状。需要进一步研究以定量测量药物稳定性。
