Verrotti A, Lobefalo L, Chiarelli F, Mastropasqua L, Gallenga P E, Morgese G
Department of Pediatrics, University G. D'Annunzio, Chieti, Italy.
Panminerva Med. 1994 Dec;36(4):179-83.
In order to evaluate the relationship between diabetic retinopathy and diabetic nephropathy we studied 55 (25 females, 30 males) retinopathic diabetic children and adolescents: their age ranged from 9.0 to 17.3 (mean +/- SD 13.9 + 3.8) years and the duration of disease from 4.8 to 10.0 (6.9 +/- 3.1) years. The mean glycosilated haemoglobin (HbA1c) was 10.4 + 2.7%. Patient distribution in relation to retinal grading showed that the greatest number of patients (34: 61.82%) were in 14-20 retinopathy level (with minimal signs of retinopathy), 9 patients showed 31 retinopathy level (16.36%) and 12 (21.82%) were in the other classes. Comparison between retinal grading of retinopathy and presence/absence of microalbuminuria showed a significant difference between the evaluated subgroups (p < 0.0001). In fact, only 6 patients out of 34 (17.64%) in class 14-20 retinopathy level, 8 patients out of 16 (50%) in 31-41 retinopathy level and 5 patients out of 5 (100%) in 51 retinopathy level had microalbuminuria. Our study shows that the presence of persistent microalbuminuria is an important risk factor for diabetic retinopathy. In conclusion, we suggest that when diabetic children have persistent microalbuminuria, the eye should be carefully examined, in order to prevent a deterioration of the eye function.
为了评估糖尿病视网膜病变与糖尿病肾病之间的关系，我们研究了55名（25名女性，30名男性）患有视网膜病变的糖尿病儿童和青少年：他们的年龄在9.0至17.3岁（平均±标准差为13.9 + 3.8岁）之间，病程为4.8至10.0年（6.9±3.1年）。糖化血红蛋白（HbA1c）的平均值为10.4 + 2.7%。根据视网膜分级的患者分布情况显示，最大数量的患者（34名：61.82%）处于14 - 20级视网膜病变水平（视网膜病变迹象最少），9名患者显示为31级视网膜病变水平（16.36%），12名患者（21.82%）处于其他级别。视网膜病变分级与微量白蛋白尿的有无之间的比较显示，评估的亚组之间存在显著差异（p < 0.0001）。实际上，在14 - 20级视网膜病变水平的34名患者中，只有6名（17.64%）有微量白蛋白尿，在31 - 41级视网膜病变水平的16名患者中有8名（50%）有微量白蛋白尿，在51级视网膜病变水平的5名患者中有5名（100%）有微量白蛋白尿。我们的研究表明，持续性微量白蛋白尿的存在是糖尿病视网膜病变的一个重要危险因素。总之，我们建议当糖尿病儿童出现持续性微量白蛋白尿时，应仔细检查眼睛，以防止眼功能恶化。
