Foley G L, Zachary J F
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
Vet Pathol. 1995 May;32(3):309-11. doi: 10.1177/030098589503200313.
A 1-year-old mixed breed heifer was presented to the Veterinary Medical Teaching Hospital at the University of Illinois with a 3-day history of abnormal mentation and aggressive behavior. Based on the history and clinical examination, euthanasia and necropsy were recommended. The differential diagnosis included rabies, pseudorabies, and a brain abscess. The brain was removed within 60 minutes of death, and the section submitted for fluorescent antibody testing was positive for rabies virus antigen. Residual brain tissue was immersion fixed in 10% neutral buffered formalin. Histologic examination revealed a marked perivascular and meningeal lymphocytic meningoencephalitis and locally extensive spongiform change of the gray matter affecting the neuropil and neuron cell bodies. The most severely affected regions with spongiform change were the thalamus and cerebral cortex. No Negri bodies were found in any sections. Since the outbreak of bovine spongiform encephalopathy (BSE) in the United Kingdom, there has been an increased surveillance of bovine neurologic cases in an effort to assess if BSE has occurred in the USA. In areas where rabies virus is endemic, rabies should be included as a possible differential diagnosis in cases of spongiform changes of the central nervous system.
一头1岁的杂种小母牛被送到伊利诺伊大学兽医学院教学医院，有3天精神异常和攻击行为的病史。根据病史和临床检查，建议实施安乐死并进行尸检。鉴别诊断包括狂犬病、伪狂犬病和脑脓肿。在死亡后60分钟内取出大脑，送检的荧光抗体检测切片狂犬病病毒抗原呈阳性。剩余脑组织浸入10%中性缓冲福尔马林中固定。组织学检查显示有明显的血管周围和脑膜淋巴细胞性脑膜脑炎，灰质局部广泛出现海绵状变化，累及神经纤维网和神经元细胞体。海绵状变化最严重的区域是丘脑和大脑皮层。所有切片均未发现内基小体。自英国爆发牛海绵状脑病（BSE）以来，美国加强了对牛神经病例的监测，以评估美国是否发生了BSE。在狂犬病病毒流行地区，对于中枢神经系统出现海绵状变化的病例，应将狂犬病纳入可能的鉴别诊断。
