Kuijpers A L, Alkemade H A, Schalkwijk J, van de Kerkhof P C
Department of Dermatology, University Hospital Nijmegen, The Netherlands.
Acta Derm Venereol. 1995 Mar;75(2):110-3. doi: 10.2340/0001555575110113.
We have assessed the distribution pattern of a new epidermal elastase inhibitor, skin-derived antileukoproteinase (SKALP) and polymorphonuclear leukocytes (PMN) in a patient with annular pustular psoriasis, using immunohistochemical methods. In clinically uninvolved skin SKALP was not expressed and only occasionally a few PMN could be identified. In the erythematous distal margin of the lesion, expression of SKALP was shown in suprabasal keratinocytes. Although PMN were present in the dermis, no transepidermal PMN migration had occurred at this stage. In the pustular region a dense SKALP-positive zone was demonstrated in the suprabasal compartment. In the centrally healed area neither SKALP expression nor PMN accumulation was shown. The present case report suggests that the induction of SKALP expression does not result from the passage of PMN through the epidermis. The offswitch of SKALP expression coincides with the disappearance of the PMN infiltration and not with the resolution of the mononuclear infiltrate.
我们采用免疫组化方法评估了一名环状脓疱型银屑病患者体内一种新型表皮弹性蛋白酶抑制剂——皮肤源性抗白细胞蛋白酶（SKALP）和多形核白细胞（PMN）的分布模式。在临床上未受累的皮肤中，未检测到SKALP表达，仅偶尔能识别出少数PMN。在皮损的红斑远端边缘，基底上层角质形成细胞中显示有SKALP表达。尽管真皮中有PMN存在，但此阶段尚未发生PMN经表皮迁移。在脓疱区域，基底上层隔室显示出密集的SKALP阳性区。在中央愈合区域，未显示SKALP表达和PMN聚集。本病例报告表明，SKALP表达的诱导并非由PMN穿过表皮所致。SKALP表达的关闭与PMN浸润的消失一致，而非与单核细胞浸润的消退一致。
