Van de Kerkhof P C, Kuppens L H, Van Vlijmen Y, Schalkwijk J
Department of Dermatology, University Hospital Nijmegen, The Netherlands.
Br J Dermatol. 1991 Jan;124(1):10-2. doi: 10.1111/j.1365-2133.1991.tb03275.x.
Two new elastase inhibitors (SKALP, skin-derived antileucoproteases) were recently described in the lesional skin in psoriasis. The present study investigated the distribution of SKALP activity in the marginal zone of spreading psoriatic plaques. In a 4-mm zone immediately adjacent to the erythemato-squamous plaques, SKALP activity was slightly increased compared to distant uninvolved skin. Within the lesion the anti-elastase activity was pronounced, but was significantly higher in the central zone of the plaque compared to the periphery. The appearance of SKALP in the psoriatic lesion appears to be a late event compared to endothelial involvement, intraepidermal accumulation of PMNs, epidermal proliferation and abnormal keratinization. This observation lends further support for the hypothesis that the induction of anti-elastase activity is associated with the off-switch of cutaneous inflammation.
最近在银屑病的皮损中发现了两种新的弹性蛋白酶抑制剂（SKALP，皮肤源性抗白细胞蛋白酶）。本研究调查了SKALP活性在进行期银屑病斑块边缘区域的分布情况。在紧邻红斑鳞屑性斑块的4毫米区域内，与远处未受累皮肤相比，SKALP活性略有增加。在皮损内，抗弹性蛋白酶活性明显，但斑块中央区域的活性明显高于周边区域。与内皮细胞受累、中性粒细胞在表皮内积聚、表皮增殖和异常角化相比，SKALP在银屑病皮损中的出现似乎是一个较晚的事件。这一观察结果进一步支持了抗弹性蛋白酶活性的诱导与皮肤炎症的消退相关这一假说。
