Onaolapo J A
Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharm. Sciences, A.B.U., Zaria.
Afr J Med Med Sci. 1994 Sep;23(3):215-9.
The cross-resistance between the aminoglycoside antibiotics, gentamycin, tobramycin, kanamycin and streptomycin was tested using clinical isolates of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus obtained from Ahmadu Bello University Teaching Hospital Zaria, Nigeria (ABUTH). The antibiotics can be classified into two groups: the kanamycin and streptomycin group on one hand to which isolates easily acquired resistance, and the amikacin, gentamycin and tobramycin group on the other to which the isolates did not easily develop resistance. There seems not to be any hard and fast rule that can be applied to the cross-resistance between these aminoglycoside antibiotics. The isolates varied markedly in their pattern of cross-resistance towards the different antibiotics.
使用从尼日利亚扎里亚阿哈穆杜·贝洛大学教学医院（ABUTH）获得的大肠埃希菌、铜绿假单胞菌和金黄色葡萄球菌临床分离株，对氨基糖苷类抗生素庆大霉素、妥布霉素、卡那霉素和链霉素之间的交叉耐药性进行了检测。这些抗生素可分为两组：一方面是卡那霉素和链霉素组，分离株很容易对其产生耐药性；另一方面是阿米卡星、庆大霉素和妥布霉素组，分离株不容易对其产生耐药性。似乎没有任何严格的规则可应用于这些氨基糖苷类抗生素之间的交叉耐药性。分离株对不同抗生素的交叉耐药模式差异显著。
