Vasina T A, Ved'mina E A, Ismagulova G D
Antibiotiki. 1975 Oct;20(10):941-5.
Effectiveness of antibacterial drugs from the group of aminoglycoside antibiotics,i.e. kanamycin, gentamycin and tobramycin with respect to the main causative agents of surgical infections, i.e. Staphylococcus, Coli bacteria, Proteus and Ps. aeruginosa was shown. The highest activity against Ps. aeruginosa was registered to tobramycin. The aminoglycoside antibiotics were satisfactorily absorbed after their intramuscular administration providing therapeutic levels of the antibiotics in the blood. For instance, administration of gentamycin in a dose of 80 mg and tobramycin in a dose of 50 mg 1-2 times a day provided the blood levels higher than the minimun inhibitory concentrations for most strains of gramnegative flora including Ps. aeruginosa. The use of the above drugs in theraphy and prophylaxis of infections caused by Ps. aeruginosa is expedient.
已表明氨基糖苷类抗生素组中的抗菌药物，即卡那霉素、庆大霉素和妥布霉素，对手术感染的主要病原体，即葡萄球菌、大肠杆菌、变形杆菌和铜绿假单胞菌的有效性。对铜绿假单胞菌活性最高的是妥布霉素。氨基糖苷类抗生素肌肉注射后吸收良好，能在血液中达到治疗水平的抗生素浓度。例如，每天1 - 2次给予80毫克剂量的庆大霉素和50毫克剂量的妥布霉素，能使血液浓度高于包括铜绿假单胞菌在内的大多数革兰氏阴性菌菌株的最低抑菌浓度。将上述药物用于治疗和预防由铜绿假单胞菌引起的感染是适宜的。
