[Some data from studying and using aminoglycoside antibiotics in reconstructive surgery].

Effectiveness of antibacterial drugs from the group of aminoglycoside antibiotics,i.e. kanamycin, gentamycin and tobramycin with respect to the main causative agents of surgical infections, i.e. Staphylococcus, Coli bacteria, Proteus and Ps. aeruginosa was shown. The highest activity against Ps. aeruginosa was registered to tobramycin. The aminoglycoside antibiotics were satisfactorily absorbed after their intramuscular administration providing therapeutic levels of the antibiotics in the blood. For instance, administration of gentamycin in a dose of 80 mg and tobramycin in a dose of 50 mg 1-2 times a day provided the blood levels higher than the minimun inhibitory concentrations for most strains of gramnegative flora including Ps. aeruginosa. The use of the above drugs in theraphy and prophylaxis of infections caused by Ps. aeruginosa is expedient.