Shaker J L, Brickner R C, Divgi A B, Raff H, Findling J W
Department of Medicine, St. Luke's Medical Center, Milwaukee, Wisconsin, USA.
Am J Med Sci. 1995 Jul;310(1):38-41. doi: 10.1097/00000441-199507000-00011.
Renal phosphate wasting related to a tumor (oncogenous osteomalacia) is a rare disorder usually associated with benign mesenchymal tumors. In this article, the authors describe a man with renal phosphate wasting and the syndrome of inappropriate antidiuretic hormone associated with small cell carcinoma. Chemotherapy markedly reduced tumor burden and was associated with normalization of renal phosphate handling and serum sodium. With recurrence, renal phosphate wasting and the syndrome of inappropriate antidiuretic hormone developed again, with the additional complication of hypercortisolism secondary to ectopic corticotropin production. The authors report the rare occurrence of renal phosphate wasting with small cell carcinoma (5 previously reported cases) and the unique co-existence of this paraneoplastic syndrome with the syndrome of inappropriate antidiuretic hormone and ectopic corticotropin production.
与肿瘤相关的肾性磷酸盐消耗（肿瘤性骨软化症）是一种罕见的疾病，通常与良性间充质肿瘤有关。在本文中，作者描述了一名患有肾性磷酸盐消耗以及与小细胞癌相关的抗利尿激素分泌不当综合征的男性患者。化疗显著减轻了肿瘤负荷，并使肾磷酸盐处理和血清钠恢复正常。随着肿瘤复发，肾性磷酸盐消耗和抗利尿激素分泌不当综合征再次出现，还出现了因异位促肾上腺皮质激素分泌导致的高皮质醇血症这一并发症。作者报告了小细胞癌伴肾性磷酸盐消耗的罕见病例（此前有5例报告），以及这种副肿瘤综合征与抗利尿激素分泌不当综合征和异位促肾上腺皮质激素分泌并存的独特情况。
