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自发性小鼠肝细胞肿瘤在通过肠胃外给药快速铁负荷期间对铁积累的抗性及其可移植性。

The resistance of spontaneous mouse hepatocellular neoplasms to iron accumulation during rapid iron loading by parenteral administration and their transplantability.

作者信息

Williams G M, Hirota N, Rice J M

出版信息

Am J Pathol. 1979 Jan;94(1):65-74.

PMID:760541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2042232/
Abstract

Spontaneous mouse liver nodules were found to be resistant to iron accumulation induced either by dietary overload or by a rapid protocol of subcutaneous injection of iron dextran. Transplants of 11 liver nodules into the mammary fat pad gave rise to neoplastic growth. Transplants of the less differentiated nodules grew more frequently and rapidly than better differentiated nodules and produced pulmonary metastases. Therefore, these mouse liver nodules are considered to be neoplasms, and their resistance to iron accumulation suggests that this marker will be useful in studying their histogenesis.

摘要

自发性小鼠肝结节被发现对饮食过量或皮下注射葡聚糖铁快速方案诱导的铁积累具有抗性。将11个肝结节移植到乳腺脂肪垫中会引发肿瘤生长。分化程度较低的结节移植比分化较好的结节更频繁、更快速地生长，并产生肺转移。因此，这些小鼠肝结节被认为是肿瘤，它们对铁积累的抗性表明该标志物将有助于研究其组织发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/f50ebcefc09f/amjpathol00245-0083-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/d9f00cfe08f9/amjpathol00245-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/910d71a1e0d5/amjpathol00245-0082-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/ad0799a5a804/amjpathol00245-0082-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/2253b6b29ddf/amjpathol00245-0082-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/7e0a31f7c858/amjpathol00245-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/fd7eb40582ec/amjpathol00245-0083-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/b5ce593022d1/amjpathol00245-0083-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/f50ebcefc09f/amjpathol00245-0083-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/d9f00cfe08f9/amjpathol00245-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/910d71a1e0d5/amjpathol00245-0082-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/ad0799a5a804/amjpathol00245-0082-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/2253b6b29ddf/amjpathol00245-0082-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/7e0a31f7c858/amjpathol00245-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/fd7eb40582ec/amjpathol00245-0083-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/b5ce593022d1/amjpathol00245-0083-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/700a/2042232/f50ebcefc09f/amjpathol00245-0083-d.jpg

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引用本文的文献

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Iron and neoplasia.铁与肿瘤。
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2
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Carcinogenesis. 2013 Sep;34(9):2184-91. doi: 10.1093/carcin/bgt164. Epub 2013 May 13.
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Hepatocarcinogenesis in the mouse. Combined morphologic-stereologic studies.小鼠肝癌发生。形态学与体视学联合研究

本文引用的文献

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Transplantation of spontaneous and induced hepatomas in inbred mice.
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Differentiation of malignant to benign cells.恶性细胞向良性细胞的分化。
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Histochemical characteristics of spontaneous and chemically induced hepatocellular neoplasms in mice and the development of neoplasms with gamma-glutamyl transpeptidase activity during phenobarbital exposure.小鼠自发性和化学诱导性肝细胞肿瘤的组织化学特征以及苯巴比妥暴露期间具有γ-谷氨酰转肽酶活性的肿瘤的发展
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Role of diaxial versus diequatorial hydroxyl groups in the tumorigenic activity of a benzo[a]pyrene bay-region diol epoxide.苯并[a]芘湾区二醇环氧化物致瘤活性中双轴羟基与双赤道羟基的作用。
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Enhancing effect of ethanol on aflatoxin B1-induced hepatocarcinogenesis in male ACI/N rats.乙醇对雄性 ACI/N 大鼠黄曲霉毒素 B1 诱导的肝癌发生的增强作用。
Jpn J Cancer Res. 1989 Jun;80(6):526-30. doi: 10.1111/j.1349-7006.1989.tb01671.x.
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Am J Pathol. 1979 May;95(2):317-28.
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The predictive value of mouse liver tumour induction in carcinogenicity testing--a literature survey.
Int J Cancer. 1973 Jul 15;12(1):1-20. doi: 10.1002/ijc.2910120102.
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Neoplasms, differentiations and mutations.肿瘤、分化与突变。
Am J Pathol. 1974 Oct;77(1):103-118.
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The toxicology of dieldrin (HEOD). I. Long-term oral toxicity studies in mice.狄氏剂（六氯环氧八氢二甲萘）的毒理学。I. 小鼠长期口服毒性研究。
Food Cosmet Toxicol. 1973 Jun;11(3):415-32. doi: 10.1016/0015-6264(73)90007-2.
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Food Cosmet Toxicol. 1972 Jun;10(3):418-26.
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