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The persistence and phenotypic stability of transplanted rat liver neoplastic nodules.

作者信息

Williams G M, Ohmori T, Watanabe K

出版信息

Am J Pathol. 1980 Apr;99(1):1-12.

PMID:7361853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1903470/
Abstract

Fragments of normal rat liver and nodular hepatocellular lesions produced by feeding rats 0.02% N-2-fluorenylacetamide for 20 weeks were transplanted into the inguinal mammary fat pad of syngeneic male rats. Five of 29 fragments of normal liver survived in the transplant site for up to 32 weeks after transplantation. Six of 20 nodules classified as neoplastic nodules and 2 of 5 with atypicality persisted and retained their morphologic abnormalities. Persisting fragments of normal liver accumulated iron when the recipient rats were iron-loaded by the feeding of 8-hydroxyquinoline and ferrous gluconate, but the nodule cells remained resistant to iron accumulation. Mitotic figures were present in nodule cells, but progressive growth did not occur. Four carcinoma transplants readily gave rise to tumors. Three of the tumors that developed in the transplant site from carcinomas were well-differentiated adenocarcinomas with mucin production. It was concluded that rat liver neoplastic nodules are phenotypically stable but differ from liver carcinomas in their biologic behavior in this system.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/87e5d3b6d264/amjpathol00230-0019-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/4025fce43aff/amjpathol00230-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/0d03df137f76/amjpathol00230-0022-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/9bbe3525a652/amjpathol00230-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/6e56c8e67787/amjpathol00230-0020-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/cf7a40a8521b/amjpathol00230-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/7485d2ac8bff/amjpathol00230-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/a2dd7eb8f7cb/amjpathol00230-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/87e5d3b6d264/amjpathol00230-0019-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/4025fce43aff/amjpathol00230-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/0d03df137f76/amjpathol00230-0022-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/9bbe3525a652/amjpathol00230-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/6e56c8e67787/amjpathol00230-0020-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/cf7a40a8521b/amjpathol00230-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/7485d2ac8bff/amjpathol00230-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/a2dd7eb8f7cb/amjpathol00230-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/1903470/87e5d3b6d264/amjpathol00230-0019-b.jpg

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The persistence and phenotypic stability of transplanted rat liver neoplastic nodules.
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引用本文的文献

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In vivo and in vitro test for growth potential of liver cells from rats during early stage of hepatocarcinogenesis by 3'-methyl-4-dimethylaminoazobenzene.

本文引用的文献

1
MORPHOLOGIC AND BIOLOGIC CORRELATION OF LESIONS OBTAINED IN HEPATIC CARCINOGENESIS IN A X C RATS GIVEN 0.025 PERCENT N-2-FLUORENYLDIACETAMIDE.给予0.025% N-2-芴基二乙酰胺的AxC大鼠肝癌发生过程中所获病变的形态学与生物学相关性
J Natl Cancer Inst. 1963 Dec;31:1407-29.
2
Role of injury and hyperplasia in the induction of hepatocellular carcinoma.损伤与增生在肝细胞癌诱导中的作用。
JAMA. 1961 Nov 18;178:729-31. doi: 10.1001/jama.1961.73040460007007b.
3
The carcinogenic effect of aramite in rats. A study of hepatic nodules.杀螨酯对大鼠的致癌作用。肝结节研究。
用3'-甲基-4-二甲基氨基偶氮苯对大鼠肝癌发生早期肝细胞生长潜力的体内和体外试验
J Cancer Res Clin Oncol. 1989;115(1):1-8. doi: 10.1007/BF00391592.
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The stem cells of the liver--a selective review.肝脏干细胞——一篇选择性综述。
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Cancer. 1960 Sep-Oct;13:1035-46. doi: 10.1002/1097-0142(196009/10)13:5<1035::aid-cncr2820130526>3.0.co;2-x.
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On the origin of malignant cells in experimental liver cancer.论实验性肝癌中恶性细胞的起源
Acta Unio Int Contra Cancrum. 1959;15(1):152-3.
5
Histopathology of carcinogenesis and tumors of the liver in rats.大鼠肝脏致癌作用及肿瘤的组织病理学
J Natl Cancer Inst. 1955 Apr;15(5, Suppl.):1427-42.
6
Further studies on the transplantation of lesions in hepatic carcinogenesis in rats given 2-(diacetamido)fluorene.
Gan. 1967 Dec;58(6):513-20.
7
Carcinoma after malignant conversion in vitro of epithelial-like cells from rat liver following exposure to chemical carcinogens.大鼠肝脏上皮样细胞在接触化学致癌物后体外恶性转化形成的癌
Cancer Res. 1973 Mar;33(3):606-12.
8
Absence of stainable iron from preneoplastic and neoplastic lesions in rat liver with 8-hydroxyquinoline-induced siderosis.8-羟基喹啉诱导大鼠肝脏铁沉着症时，癌前病变和肿瘤病变中无可染铁。
J Natl Cancer Inst. 1972 Sep;49(3):685-92.
9
Sequential morphologic changes in aflatoxin B carcinogenesis in the rat.大鼠黄曲霉毒素B致癌过程中的序贯形态学变化
Cancer Res. 1968 Apr;28(4):770-81.
10
Nature of early appearing, carcinogen-induced liver lesions to iron accumulation.早期出现的致癌物诱导的肝脏病变与铁蓄积的性质。
J Natl Cancer Inst. 1976 Jul;57(1):157-65. doi: 10.1093/jnci/57.1.157.