Latchman D S, Isenberg D A
Department of Molecular Pathology, University College London Medical School.
Autoimmunity. 1994;19(3):211-8. doi: 10.3109/08916939408995696.
The heat shock proteins are a group of evolutionarily conserved proteins with important physiological functions, whose synthesis is enhanced by elevated temperature or other stresses. A role for one or more of these proteins in human autoimmune disease has been extensively discussed. This review considers the evidence of a role for hsp90 in systemic lupus erythematosus (SLE) where overexpression of this protein, its surface localization and auto-antibodies to it have been observed in both human patients and in the MRL/lpr mouse model of SLE.
热休克蛋白是一组具有重要生理功能的进化保守蛋白，其合成会因温度升高或其他应激而增强。其中一种或多种蛋白在人类自身免疫性疾病中的作用已被广泛讨论。本综述考虑了热休克蛋白90（hsp90）在系统性红斑狼疮（SLE）中作用的证据，在人类患者和SLE的MRL/lpr小鼠模型中均观察到该蛋白的过表达、其表面定位以及针对它的自身抗体。
