Stoppe G, Schütze R, Kögler A, Staedt J, Munz D L, Emrich D, Rüther E
Department of Psychiatry, University of Göttingen, Germany.
Dementia. 1995 Mar-Apr;6(2):73-82. doi: 10.1159/000106925.
Neuropathological reports about denervation and amyloid angiopathy in dementia of Alzheimer's type (DAT) as well as signs of selective incomplete white matter infarctions point to a vascular involvement within the degenerative process. In order to investigate potential alterations of cerebrovascular function we performed cerebral blood flow measurements before and after intravenous injection of 1 g acetazolamide using technetium-99m hexamethylpropyleneamine oxime and single photon emission tomography in 12 patients (6 female, 6 male; mean age 70.8 +/- 9.6 years) with probable (senile) dementia of Alzheimer's type (SDAT) and 9 controls (7 female, 2 male; mean age 71.2 +/- 8.6 years). SDAT patients revealed significantly reduced cerebrovascular reactivity with lower values with increasing cognitive impairment. We discuss possible underlying mechanisms.
关于阿尔茨海默病型痴呆（DAT）中去神经支配和淀粉样血管病的神经病理学报告以及选择性不完全白质梗死的迹象表明，在退行性过程中存在血管受累情况。为了研究脑血管功能的潜在改变，我们对12例可能患有（老年性）阿尔茨海默病型痴呆（SDAT）的患者（6名女性，6名男性；平均年龄70.8±9.6岁）和9名对照者（7名女性，2名男性；平均年龄71.2±8.6岁），在静脉注射1克乙酰唑胺前后，使用锝-99m六甲基丙烯胺肟和单光子发射断层扫描进行了脑血流量测量。SDAT患者显示出脑血管反应性显著降低，且随着认知障碍加重，数值更低。我们讨论了可能的潜在机制。
