Stone S, Jiang P, Dayananth P, Tavtigian S V, Katcher H, Parry D, Peters G, Kamb A
Myriad Genetics, Inc., Salt Lake City, Utah 84018, USA.
Cancer Res. 1995 Jul 15;55(14):2988-94.
The p16 gene (P16, MTS1, CDKN2) encodes a negative regulator of the cell cycle. Molecular genetic techniques have been used to explore the role of p16 in normal development and cancer. Two transcripts derived from the p16 gene with distinct protein coding potentials are described. The previously undescribed transcript form has the same exons 2 and 3 as the p16-encoding mRNA but contains a different exon 1. The human p16 transcripts are detected in various tissues, and the ratio of the transcripts is regulated in both a tissue-specific and cell cycle-specific manner. The P16-derived mRNAs are probably generated from separate promoters, and transcription from one of the promoters appears to be regulated, at least in part, by the retinoblastoma gene product.
p16基因（P16、MTS1、CDKN2）编码细胞周期的负调控因子。分子遗传学技术已被用于探索p16在正常发育和癌症中的作用。本文描述了p16基因产生的两种具有不同蛋白质编码潜能的转录本。之前未被描述的转录本形式与编码p16的mRNA具有相同的外显子2和3，但包含一个不同的外显子1。人类p16转录本在各种组织中均有检测到，并且转录本的比例以组织特异性和细胞周期特异性的方式受到调控。源自P16的mRNA可能由不同的启动子产生，并且至少部分地，其中一个启动子的转录似乎受视网膜母细胞瘤基因产物的调控。
