Klockars M, Pettersson T, Riska H, Hellström P E, Norhagen A
Arch Intern Med. 1979 Jan;139(1):73-7.
Lysozyme content was measured in the plasma and pleural fluid of 110 patients with pleural effusions of various causes. The concentration of pleural fluid lysozyme was significantly higher (P less than .001) in patients with tuberculous pleurisy than in those with primary pulmonary carcinoma, metastatic carcinoma of the lung, connective tissue disease, nonspecific pleurisy, or congestive heart failure. Tuberculous patients also had a significantly higher (P less than .001) pleural fluid-to-plasma lysozyme ratio than did the other patients. Plasma lysozyme activity did not differ significantly among the various patient groups. Lysozyme was identified immunohistochemically in epithelioid cell granulomas in tuberculosis, in activated macrophages in lymph nodes adjacent to tuberculous lesions, and in granulocytes in pleural empyema. No lysozyme was detected in neoplastic cells in pulmonary carcinoma. The results show that the determination of pleural fluid lysozyme is a simple, fast method for obtaining corroborative information in the differential diagnosis of tuberculous pleurisy.
对110例各种病因所致胸腔积液患者的血浆和胸腔积液中的溶菌酶含量进行了测定。结核性胸膜炎患者胸腔积液中溶菌酶浓度显著高于原发性肺癌、肺转移性癌、结缔组织病、非特异性胸膜炎或充血性心力衰竭患者（P<0.001）。结核患者的胸腔积液与血浆溶菌酶比值也显著高于其他患者（P<0.001）。不同患者组间血浆溶菌酶活性无显著差异。通过免疫组织化学方法在结核的上皮样细胞肉芽肿、结核病变附近淋巴结的活化巨噬细胞以及胸腔积脓的粒细胞中鉴定出溶菌酶。在肺癌的肿瘤细胞中未检测到溶菌酶。结果表明，测定胸腔积液溶菌酶是在结核性胸膜炎鉴别诊断中获取佐证信息的一种简单、快速的方法。
