Ma Z W, Pejovic T, Najfeld V, Ward D C, Johnson E M
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Cytogenet Cell Genet. 1995;71(1):64-7. doi: 10.1159/000134065.
Pur alpha (PurA) is a sequence-specific single-stranded-DNA-binding protein implicated in control of both DNA replication and transcription. We have localized the Pur alpha gene (PURA) to human chromosome band 5q31 by fluorescence in situ hybridization with a 16-kb genomic probe together with hybridization of a cDNA probe to blots of DNA from human-hamster cell lines containing individual human chromosomes. Sequences with homology to the PURA locus are also present at 6q14. The 5q31 locus is frequently deleted in myelogenous leukemia and other cancers.
嘌呤α（PurA）是一种序列特异性单链DNA结合蛋白，参与DNA复制和转录的调控。我们通过用一个16kb的基因组探针进行荧光原位杂交，以及将一个cDNA探针与来自含有单个人类染色体的人-仓鼠细胞系的DNA印迹杂交，将Purα基因（PURA）定位到人类染色体5q31带。与PURA基因座具有同源性的序列也存在于6q14。5q31基因座在髓性白血病和其他癌症中经常缺失。
