Carman J S, Wyatt R J
Arch Gen Psychiatry. 1979 Jan;36(1):72-5. doi: 10.1001/archpsyc.1979.01780010078008.
Synthetic salmon calcitonin was administered subcutaneously to 12 inpatients with several primary psychotic diagnoses. Increases in serum total calcium and inorganic phosphorus levels and decreases in CSF calcium level had earlier been observed during periodic psychotic agitation or mania. By contrast, calcitonin, which decreased serum calcium and phosphorus levels and increased CSF calcium level, appeared to produce transient (24-hour) increases in depression and decreases in arousal in this double-blind placebo-controlled trial. Quantitative activity monitoring confirmed the rater's impression that this agent had tranquilizing or depressant effects in such patients. When given in the evening, this polypeptide also appeared to delay sleep onset, as demonstrated both by nurses' 30-minute sleep checks and by the same longitudinal activity record. A decreased hypocalcemic response to calcitonin was noted in the agitated patients, which might explain the increases in serum calcium level described at the "switch".
对12例患有多种原发性精神病诊断的住院患者皮下注射合成鲑鱼降钙素。先前在周期性精神病性激越或躁狂期间观察到血清总钙和无机磷水平升高以及脑脊液钙水平降低。相比之下，在这项双盲安慰剂对照试验中，降钙素降低了血清钙和磷水平并升高了脑脊液钙水平，似乎产生了短暂（24小时）的抑郁增加和觉醒降低。定量活动监测证实了评估者的印象，即该药物在此类患者中具有镇静或抑制作用。晚上给药时，这种多肽似乎也会延迟入睡，护士的30分钟睡眠检查和相同的纵向活动记录均证明了这一点。在激越患者中观察到对降钙素的低钙血症反应降低，这可能解释了在“转换”时所描述的血清钙水平升高。
