Carman J S, Wyatt R J
Am J Psychiatry. 1979 Aug;136(8):1035-9. doi: 10.1176/ajp.136.8.1035.
In this double-blind study dihydrotachysterol (DHT) was given orally to eight psychotic patients; in each case marked increases in psychosis and agitation accompanied increases in serum calcium and phosphorus within two weeks after active drug was substituted for placebo. In the three patients whose psychoses exhibited periodic spontaneous exacerbations, the agitated episodes grew more severe. Serum creatine phosphokinase (CPK) increased in all but one patient. By contrast, when three periodically psychotic patients received synthetic salmon calcitonin (SCT), the severity and frequency of agitated episodes decreased while CSF calcium increased in all three. These data support the hypothesis that the observed abrupt increases in serum calcium and phosphorus might cause the opposite CSF calcium shifts, the behavioral agitation and the increases in serum CPK frequently noted during acute psychosis.
在这项双盲研究中，对8名精神病患者口服双氢速甾醇（DHT）；在每种情况下，在活性药物替代安慰剂后的两周内，随着血清钙和磷的增加，精神病症状和躁动明显加重。在3名精神病呈周期性自发加重的患者中，躁动发作变得更加严重。除1名患者外，所有患者的血清肌酸磷酸激酶（CPK）均升高。相比之下，当3名周期性精神病患者接受合成鲑鱼降钙素（SCT）时，躁动发作的严重程度和频率降低，而所有3名患者的脑脊液钙均升高。这些数据支持这样一种假设，即观察到的血清钙和磷的突然增加可能导致相反的脑脊液钙变化、行为躁动以及急性精神病期间经常出现的血清CPK升高。
