氯磺丙脲的生物利用度。
Bioavailability of chlorpropamide.
作者信息
Evans M, Glass R C, Mitchard M, Munday B M, Yates R
出版信息
Br J Clin Pharmacol. 1979 Jan;7(1):101-5. doi: 10.1111/j.1365-2125.1979.tb00904.x.
Abstract
- The serum profiles of chlorpropamide obtained following single doses of two tablet preparations and from a suspension formulation have been compared in healthy volunteers. The amounts of chlorpropamide absorbed from the three formulations were similar but the drug was absorbed more rapidly from the suspension than from either tablet formulation. There was a small but therapeutically insignificant difference in the rate of absorption of the drug from the two tablets. 2. Changes in blood glucose concentrations were found to be related to the drug serum profile characteristics of the formulations.
摘要
- 已在健康志愿者中比较了单次服用两种片剂制剂和一种混悬液制剂后获得的氯磺丙脲血清谱。从这三种制剂中吸收的氯磺丙脲量相似，但药物从混悬液中的吸收比从任何一种片剂制剂中都更快。两种片剂在药物吸收速率上存在微小但在治疗上无显著意义的差异。2. 发现血糖浓度的变化与制剂的药物血清谱特征相关。
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