急性酒精中毒对氯氮䓬代谢及血浆动力学的影响。
Effect of acute alcohol intoxication on the metabolism and plasma kinetics of chlordiazepoxide.
作者信息
Whiting B, Lawrence J R, Skellern G G, Meier J
出版信息
Br J Clin Pharmacol. 1979 Jan;7(1):95-100. doi: 10.1111/j.1365-2125.1979.tb00903.x.
Abstract
- The metabolism and plasma kinetics of chlordiazepoxide have been determined in a group of volunteers and in a group of patients with acute alcohol intoxication. 2. Using the SAAM 26 non-linear least squares fitting programme, all chlordiazepoxide plasma concentration v time data following oral administration could be analysed in terms of a one-compartment open model with metabolic conversion of chlordiazepoxide to desmethylchlordiazepoxide. 3. Acutely intoxicated patients showed a prolonged elimination of chlordiazepoxide and a reduced clearance when compared with alcohol-free volunteers. The elimination of desmethylchlordiazepoxide, on the other hand, appeared to be faster in the alcoholics. 4. Alcohol exerts significant effects on the metabolism of chlordiazepoxide in acutely intoxicated patients.
摘要
- 已在一组志愿者和一组急性酒精中毒患者中测定了氯氮䓬的代谢和血浆动力学。2. 使用SAAM 26非线性最小二乘拟合程序，口服给药后所有氯氮䓬血浆浓度随时间的数据都可以根据具有氯氮䓬向去甲基氯氮䓬代谢转化的一室开放模型进行分析。3. 与无酒精的志愿者相比，急性中毒患者氯氮䓬的消除时间延长且清除率降低。另一方面，去甲基氯氮䓬在酗酒者中的消除似乎更快。4. 酒精对急性中毒患者氯氮䓬的代谢有显著影响。
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