西咪替丁不改变吗啡在人体内的处置。
Cimetidine does not alter morphine disposition in man.
作者信息
Mojaverian P, Fedder I L, Vlasses P H, Rotmensch H H, Rocci M L, Swanson B N, Ferguson R K
出版信息
Br J Clin Pharmacol. 1982 Dec;14(6):809-13. doi: 10.1111/j.1365-2125.1982.tb02041.x.
Abstract
1 The pharmacokinetic parameters of morphine were determined in a crossover fashion following 4 days pretreatment with cimetidine, 300 mg every 6 h, or placebo. 2 Cimetidine had no apparent effect on the mean morphine plasma clearance, volume of distribution, AUC or half-life (P greater than 0.05; power greater than 0.80). 3 Cimetidine had no apparent effect on the magnitude or duration of morphine induced miosis. 4 The absence of a demonstrable effect on the pharmacokinetics of a drug with a high extraction ratio such as morphine suggests that cimetidine did not significantly reduce hepatic blood flow in ambulant normal volunteers.
摘要
以交叉给药方式，在给予西咪替丁（每6小时300毫克）或安慰剂预处理4天后，测定吗啡的药代动力学参数。
西咪替丁对吗啡的平均血浆清除率、分布容积、AUC或半衰期无明显影响（P大于0.05；检验效能大于0.80）。
西咪替丁对吗啡所致瞳孔缩小的程度和持续时间无明显影响。
对于像吗啡这样具有高提取率的药物，西咪替丁未对其药代动力学产生明显影响，这表明西咪替丁在门诊正常志愿者中并未显著降低肝血流量。
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