Murphy E V, Zhang Y, Zhu W, Biggs J
Department of Neurologic Surgery, University of California, San Francisco 94143, USA.
Gene. 1995 Jun 14;159(1):131-5. doi: 10.1016/0378-1119(95)00061-a.
We report the cloning of a cDNA encoding GliPR (glioma pathogenesis-related protein), a protein that is structurally similar to plant pathogenesis-related proteins. The GLIPR gene is highly expressed in the human brain tumor, glioblastoma multiforme/astrocytoma, but neither in normal fetal or adult brain tissue, nor in other nervous system tumors. GliPR shares up to 50% amino acid (aa) homology with plant pathogenesis-related proteins, group 1, over a region that comprises almost two thirds of the protein. We speculate that there may be functional similarities between the human and plant proteins as well.
我们报道了一种编码GliPR（胶质瘤发病机制相关蛋白）的cDNA的克隆，该蛋白在结构上与植物发病机制相关蛋白相似。GLIPR基因在人脑肿瘤多形性胶质母细胞瘤/星形细胞瘤中高度表达，但在正常胎儿或成人脑组织以及其他神经系统肿瘤中均不表达。GliPR与第1组植物发病机制相关蛋白在占该蛋白近三分之二的区域内具有高达50%的氨基酸同源性。我们推测人和植物蛋白之间可能也存在功能相似性。
