Scheimberg I B, Pollock D J, Collins P W, Doran H M, Newland A C, van der Walt J D
Department of Histopathology, Royal London Hospital, UK.
Histopathology. 1995 Apr;26(4):311-21. doi: 10.1111/j.1365-2559.1995.tb00192.x.
Histopathological findings in the liver in a series of autopsies on 110 patients suffering from leukaemia or lymphoma were reviewed. No treatment had been given to 23 patients, 50 had received chemotherapy alone, 23 chemo- and radiotherapy and 14 underwent bone marrow transplantation. The 23 untreated patients showed neoplastic infiltration in 10 (44%) and fibrosis in 16 cases (70%). The 14 bone marrow recipients showed mainly acute necrosis, zonal in six (43%) and focal in one (7%), and cholestasis in five (36%), together with marked siderosis in 11 (79%). Patients receiving chemotherapy or chemo-/radiotherapy showed similar changes consisting of neoplastic infiltration in 14 (28%) and in five (22%) cases respectively, and fibrosis in 31 (62%) and 17 (74%) cases respectively. Steatosis was seen in 70% of cases in the chemo-/radiotherapy group and in 50% of cases in the other groups. Infections were seen in all groups, particularly in the chemotherapy group (four fungal and two bacterial including one tuberculosis) and in the chemo-/radiotherapy group (one fungal and one bacterial). Cytomegalovirus infection was seen only in the bone marrow transplant group.
回顾了对110例白血病或淋巴瘤患者进行的一系列尸检中肝脏的组织病理学发现。23例患者未接受治疗，50例仅接受化疗，23例接受化疗和放疗，14例接受骨髓移植。23例未治疗的患者中，10例（44%）出现肿瘤浸润，16例（70%）出现纤维化。14例骨髓移植受者主要表现为急性坏死，6例（43%）呈带状，1例（7%）呈局灶性坏死，5例（36%）出现胆汁淤积，11例（79%）有明显的含铁血黄素沉着。接受化疗或化疗/放疗的患者表现出类似变化，分别有14例（28%）和5例（22%）出现肿瘤浸润，31例（62%）和17例（74%）出现纤维化。化疗/放疗组70%的病例出现脂肪变性，其他组为50%。所有组均有感染，尤其是化疗组（4例真菌和
