基底膜现象在系统性红斑狼疮诊断中的可靠性如何？
How reliable is the basement membrane phenomenon in the diagnosis of systemic lupus erythematosus?
作者信息
al-Fouzan A S, Hassab-el-Naby H M, Dvorak R
机构信息
Department of Dermatology, Al-Sabah Hospital, Safat, Kuwait.
出版信息
Int J Dermatol. 1995 May;34(5):330-2. doi: 10.1111/j.1365-4362.1995.tb03613.x.
BACKGROUND
Although the basement membrane (BM) phenomenon is considered a good test to differentiate between systemic (SLE) and discoid lupus erythematosus (DLE), our observations question its reliability.
METHODS
Direct immunofluorescence stain was done to detect immunoglobulins and complement deposits in 10 SLE patients and in 10 healthy controls. Specimens were taken from the normal skin of the dorsa of hands.
RESULTS
The group of SLE patients showed deposits of IgG in 4, IgM in 7, IgA in 1, C3 in 7, and C4 in 1 patient. The group of healthy controls showed IgM in 2, C3 in 5, C4 in 2 cases, but no IgG or IgA deposits.
CONCLUSION
A positive BM phenomenon test could be found in normal individuals and may be due to the effect of ultraviolet rays. We think that the BM phenomenon has a limited reliability in diagnosing SLE.
背景
尽管基底膜（BM）现象被认为是区分系统性红斑狼疮（SLE）和盘状红斑狼疮（DLE）的一项良好检测，但我们的观察结果对其可靠性提出了质疑。
方法
对10例SLE患者和10例健康对照者进行直接免疫荧光染色，以检测免疫球蛋白和补体沉积。标本取自手背正常皮肤。
结果
SLE患者组中，4例出现IgG沉积，7例出现IgM沉积，1例出现IgA沉积，7例出现C3沉积，1例出现C4沉积。健康对照组中，2例出现IgM沉积，5例出现C3沉积，2例出现C4沉积，但未发现IgG或IgA沉积。
结论
在正常个体中可发现BM现象检测呈阳性，这可能是紫外线作用的结果。我们认为BM现象在诊断SLE方面的可靠性有限。
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