Ullman S, Halberg P, Wolf-Jürgensen P
Acta Derm Venereol. 1975;55(2):109-12.
Deposits of immunoglobulins and/or complement C3 were found in two-thirds of biopsies from clinically normal skin of 64 patients with systemic lupus erythematosus, as judged by well defined criteria. The incidence of deposits in clinically normal skin was identical in patients with and without clinical skin lesions. IgM was found more frequently in the deposits (88%) than was IgG (36%) but equally frequently in involved and uninvolved skin, whereas C3 was found more often in patients with skin lesions (59% in involved skin, 36% in uninvolved skin) than in patients without skin lesions (14%). The occurrence of IgG and IgA was less frequent than that of C3 but the distribution was similar to that of C3. In normal skin of 20 patients with chronic discoid LE, deposits were found in one. Deposits were found in the skin of one-third of patients with nuclear antibodies in their sera and symptoms compatible with SLE but with a score of symptoms too low to meet the criteria.
根据明确的标准判断，在64例系统性红斑狼疮患者临床正常皮肤的活检样本中，三分之二发现了免疫球蛋白和/或补体C3沉积。有临床皮肤病变和无临床皮肤病变的患者，临床正常皮肤中沉积的发生率相同。在沉积物中发现IgM的频率（88%）高于IgG（36%），但在受累皮肤和未受累皮肤中出现的频率相同，而C3在有皮肤病变的患者中（受累皮肤中为59%，未受累皮肤中为36%）比在无皮肤病变的患者中（14%）更常见。IgG和IgA的出现频率低于C3，但分布与C3相似。在20例慢性盘状红斑狼疮患者的正常皮肤中，仅1例发现沉积物。在血清中有核抗体且症状与系统性红斑狼疮相符但症状评分过低不符合标准的患者中，三分之一的患者皮肤中发现了沉积物。
