大肠杆菌中marORA序列对多重耐药性（mar）操纵子的调控
Regulation of the multiple antibiotic resistance (mar) regulon by marORA sequences in Escherichia coli.
作者信息
Martin R G, Nyantakyi P S, Rosner J L
机构信息
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892-0560, USA.
出版信息
J Bacteriol. 1995 Jul;177(14):4176-8. doi: 10.1128/jb.177.14.4176-4178.1995.
Abstract
The mar operon and adjacent sequences were subcloned on a low-copy-number plasmid to identify essential regulatory elements. A 1.1-kbp fragment containing 133 bp of the operator-promoter region (marO), the full marRA gene sequences, and only 10 of 72 marB codons provided a dela mar strain with normal repressibility and inducibility and the ability to beget mar constitutive mutants.
摘要
将mar操纵子及相邻序列亚克隆到低拷贝数质粒上，以鉴定必需的调控元件。一个1.1kbp的片段，包含133bp的操纵子-启动子区域（marO）、完整的marRA基因序列以及72个marB密码子中的仅10个，赋予了一个dela mar菌株正常的阻遏性和诱导性以及产生mar组成型突变体的能力。
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本文引用的文献
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Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli.marRAB操纵子中的阻遏物突变可激活大肠杆菌中的氧化应激基因和多重抗生素耐药性。
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