• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

When is it worth measuring a covariate in a randomized clinical trial?

作者信息

Allison D B

机构信息

Columbia University College of Physicians and Surgeons, New York, USA.

出版信息

J Consult Clin Psychol. 1995 Jun;63(3):339-43. doi: 10.1037//0022-006x.63.3.339.

DOI:10.1037//0022-006x.63.3.339
PMID:7608345
Abstract

In a randomized clinical trial, an experimenter can increase statistical power by including a covariate (e.g., a pretest). This will generally reduce the total number of participants needed to achieve a specified level of power. However, it will also increase the cost per participant. Thus, the question arises, "When do the savings incurred by needing fewer participants exceed the costs incurred by measuring each participant on the covariate?" A simple closed form expression is derived that applied researchers can use in the design phase of studies to answer this question.

摘要

相似文献

1
When is it worth measuring a covariate in a randomized clinical trial?
J Consult Clin Psychol. 1995 Jun;63(3):339-43. doi: 10.1037//0022-006x.63.3.339.
2
Power and money in cluster randomized trials: when is it worth measuring a covariate?整群随机试验中的权力与金钱:何时值得测量协变量?
Stat Med. 2006 Aug 15;25(15):2607-17. doi: 10.1002/sim.2297.
3
Covariate adjustment increases statistical power in randomized controlled trials.协变量调整可提高随机对照试验的统计效能。
J Clin Epidemiol. 2010 Dec;63(12):1391; author reply 1392-3. doi: 10.1016/j.jclinepi.2010.05.003.
4
Estimating dose-response effects in psychological treatment trials: the role of instrumental variables.估计心理治疗试验中的剂量-反应效应:工具变量的作用。
Stat Methods Med Res. 2011 Jun;20(3):191-215. doi: 10.1177/0962280208097243. Epub 2008 Nov 26.
5
Explaining community-level variance in group randomized trials.解释群组随机试验中的社区层面差异。
Stat Med. 1999 Mar 15;18(5):539-56. doi: 10.1002/(sici)1097-0258(19990315)18:5<539::aid-sim50>3.0.co;2-s.
6
Calculating sample sizes for cluster randomized trials: we can keep it simple and efficient!计算整群随机试验的样本量:我们可以保持简单和高效!
J Clin Epidemiol. 2012 Nov;65(11):1212-8. doi: 10.1016/j.jclinepi.2012.06.002.
7
On the variability of covariate adjustment. experience with Koch's method for evaluating the absolute difference in proportions in randomized clinical trials.关于协变量调整的变异性。科赫方法在评估随机临床试验中比例绝对差异方面的经验。
Control Clin Trials. 2002 Apr;23(2):127-42. doi: 10.1016/s0197-2456(01)00201-x.
8
Analytic methods for questions pertaining to a randomized pretest, posttest, follow-up design.针对随机前测、后测、随访设计相关问题的分析方法。
J Clin Child Adolesc Psychol. 2003 Sep;32(3):467-86. doi: 10.1207/S15374424JCCP3203_15.
9
Incorporating cost in power analysis for three-level cluster-randomized designs.在三级整群随机设计的功效分析中纳入成本因素。
Eval Rev. 2009 Aug;33(4):335-57. doi: 10.1177/0193841X09337991. Epub 2009 Jun 9.
10
The role of sampling in clinical trial design.采样在临床试验设计中的作用。
Psychother Res. 2011 May;21(3):243-51. doi: 10.1080/10503307.2010.549520.

引用本文的文献

1
The "SleepWell" intervention for patients with insomnia and persistent pain: a study protocol for a randomised waiting-list controlled trial of a cognitive behavioural group therapy programme.针对失眠和持续性疼痛患者的“良好睡眠”干预措施:一项认知行为团体治疗方案的随机等待名单对照试验的研究方案
Trials. 2025 Aug 27;26(1):314. doi: 10.1186/s13063-025-09041-z.
2
Misstatements, misperceptions, and mistakes in controlling for covariates in observational research.在观察性研究中对协变量进行控制时的错误陈述、误解和错误。
Elife. 2024 May 16;13:e82268. doi: 10.7554/eLife.82268.
3
Modified prolonged exposure therapy as Early Intervention after Rape (The EIR-study): study protocol for a multicenter randomized add-on superiority trial.
改良后的延长暴露疗法作为强奸后早期干预(EIR 研究):一项多中心随机附加优势试验的研究方案。
Trials. 2023 Feb 21;24(1):126. doi: 10.1186/s13063-023-07147-w.
4
Starving for nutrients: anorexia during infection with parasites in broilers is affected by diet composition.饥饿的营养:肉鸡感染寄生虫时的厌食受饮食成分的影响。
Poult Sci. 2022 Jan;101(1):101535. doi: 10.1016/j.psj.2021.101535. Epub 2021 Oct 13.
5
Errors in the implementation, analysis, and reporting of randomization within obesity and nutrition research: a guide to their avoidance.肥胖与营养研究中随机化实施、分析和报告中的错误:避免方法指南。
Int J Obes (Lond). 2021 Nov;45(11):2335-2346. doi: 10.1038/s41366-021-00909-z. Epub 2021 Jul 29.
6
The daily Self-Weighing for Obesity Management in Primary Care Study: Rationale, design and methodology.《初级保健中肥胖管理的每日自我称重研究:基本原理、设计和方法》。
Contemp Clin Trials. 2021 Aug;107:106463. doi: 10.1016/j.cct.2021.106463. Epub 2021 May 31.
7
Incorrect statistical method in parallel-groups RCT led to unsubstantiated conclusions.平行组随机对照试验中不正确的统计方法导致了毫无根据的结论。
Lipids Health Dis. 2016 Apr 15;15:77. doi: 10.1186/s12944-016-0242-3.
8
Common scientific and statistical errors in obesity research.肥胖研究中常见的科学和统计错误。
Obesity (Silver Spring). 2016 Apr;24(4):781-90. doi: 10.1002/oby.21449.
9
Best (but oft-forgotten) practices: designing, analyzing, and reporting cluster randomized controlled trials.最佳(但常常被遗忘)的实践方法:设计、分析和报告整群随机对照试验。
Am J Clin Nutr. 2015 Aug;102(2):241-8. doi: 10.3945/ajcn.114.105072. Epub 2015 May 27.
10
Concerning Sichieri R, Cunha DB: Obes Facts 2014;7:221–232. The Assertion that Controlling for Baseline (Pre-Randomization) Covariates in Randomized Controlled Trials Leads to Bias is False.关于西基耶里R、库尼亚DB:《肥胖事实》2014年;7:221 - 232。关于在随机对照试验中对基线(随机分组前)协变量进行控制会导致偏差的断言是错误的。
Obes Facts. 2015;8(2):127-9. doi: 10.1159/000381434.