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平行组随机对照试验中不正确的统计方法导致了毫无根据的结论。

Incorrect statistical method in parallel-groups RCT led to unsubstantiated conclusions.

作者信息

Allison David B, Antoine Lisa H, George Brandon J

机构信息

Nutrition Obesity Research Center and Department of Biostatistics, University of Alabama at Birmingham, Ryals Public Health Building, Room 140J, Birmingham, AL, 35294, USA.

School of Public Health, University of Alabama at Birmingham, Ryals Public Health Building, Room 140J, Birmingham, AL, 35294, USA.

出版信息

Lipids Health Dis. 2016 Apr 15;15:77. doi: 10.1186/s12944-016-0242-3.

DOI:10.1186/s12944-016-0242-3
PMID:27083538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4869669/
Abstract

The article by Aiso et al. titled "Compared with the intake of commercial vegetable juice, the intake of fresh fruit and komatsuna (Brassica rapa L. var perviridis) juice mixture reduces serum cholesterol in middle-aged men: a randomized controlled pilot study" does not meet the expected standards of Lipids in Health and Disease. Although the article concludes that there are some significant benefits to their komatsuna juice mixture, these claims are not supported by the statistical analyses used. An incorrect procedure was used to compare the differences in two treatment groups over time, and a large number of outcomes were tested without correction; both issues are known to produce high rates of false positives, making the conclusions of the study unjustified. The study also fails to follow published journal standards regarding clinical trial registration and reporting.

摘要

相泽等人发表的题为《与饮用市售蔬菜汁相比,饮用新鲜水果和小松菜(Brassica rapa L. var perviridis)汁混合物可降低中年男性的血清胆固醇:一项随机对照试验性研究》的文章未达到《健康与疾病中的脂质》的预期标准。尽管该文章得出结论称其小松菜汁混合物有一些显著益处,但这些说法并未得到所采用的统计分析的支持。在比较两个治疗组随时间的差异时使用了错误的程序,并且对大量结果进行了未经校正的检验;这两个问题都会导致高假阳性率,从而使该研究的结论不合理。该研究也未遵循已发表的关于临床试验注册和报告的期刊标准。

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