源于长期原发性侧索硬化症的运动神经元病（肌萎缩性侧索硬化症）
Motor neuron disease (amyotrophic lateral sclerosis) arising from longstanding primary lateral sclerosis.
作者信息
Bruyn R P, Koelman J H, Troost D, de Jong J M
机构信息
Department of Neurology, Oudenryn Hospital, Utrecht, The Netherlands.
出版信息
J Neurol Neurosurg Psychiatry. 1995 Jun;58(6):742-4. doi: 10.1136/jnnp.58.6.742.
Abstract
Three men were initially diagnosed as having primary lateral sclerosis (PLS), but eventually developed amyotrophic lateral sclerosis (ALS) after 7.5, 9, and at least 27 years. Non-familial ALS and PLS might be different manifestations of a single disease or constitute completely distinct entities. The clinical diagnosis of PLS predicts a median survival that is four to five times longer than in ALS.
摘要
三名男性最初被诊断为原发性侧索硬化症（PLS），但最终分别在7.5年、9年和至少27年后发展为肌萎缩侧索硬化症（ALS）。非家族性ALS和PLS可能是单一疾病的不同表现形式，或者构成完全不同的实体。PLS的临床诊断预测的中位生存期比ALS长四到五倍。
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