Bruyn R P, Koelman J H, Troost D, de Jong J M
Department of Neurology, Oudenryn Hospital, Utrecht, The Netherlands.
J Neurol Neurosurg Psychiatry. 1995 Jun;58(6):742-4. doi: 10.1136/jnnp.58.6.742.
Three men were initially diagnosed as having primary lateral sclerosis (PLS), but eventually developed amyotrophic lateral sclerosis (ALS) after 7.5, 9, and at least 27 years. Non-familial ALS and PLS might be different manifestations of a single disease or constitute completely distinct entities. The clinical diagnosis of PLS predicts a median survival that is four to five times longer than in ALS.
三名男性最初被诊断为原发性侧索硬化症（PLS），但最终分别在7.5年、9年和至少27年后发展为肌萎缩侧索硬化症（ALS）。非家族性ALS和PLS可能是单一疾病的不同表现形式，或者构成完全不同的实体。PLS的临床诊断预测的中位生存期比ALS长四到五倍。
