Somacarrera M L, Hernández G, Acero J, Moskow B S
Complutense University, Faculty of Dentistry, Department of Oral Medicine and Surgery, Madrid, Spain.
J Periodontol. 1994 Jul;65(7):671-5. doi: 10.1902/jop.1994.65.7.671.
A longitudinal study was conducted during the first 6 months following transplant surgery in 100 heart, liver, or kidney transplant patients to assess the incidence and severity of cyclosporin-induced gingival overgrowth, as well as the most important associated factors. Gingival overgrowth, plaque, and gingivitis indices, in addition to cyclosporin blood concentration, were assessed monthly. Statistical analysis was applied to evaluate the relationship between gingival overgrowth and other study variables and to test the influence of age, sex, time, and transplant type. Forty-three percent (43%) of the patients developed gingival overgrowth. Gingival overgrowth increased significantly during the study, while plaque and gingivitis, subject to an oral hygiene training and motivation program, decreased significantly. The findings from this study would suggest that the basic factor influencing gingival overgrowth is cyclosporin blood concentration, followed by plaque/gingivitis level. The significant differences observed among transplant types, as well as among age groups, might be attributed to the differences in cyclosporin concentrations. An oral hygiene program prior to the transplant surgery is recommended.
对100名心脏、肝脏或肾脏移植患者进行了一项纵向研究，研究时间为移植手术后的前6个月，以评估环孢素引起的牙龈增生的发生率和严重程度，以及最重要的相关因素。除了环孢素血药浓度外，每月还评估牙龈增生、菌斑和牙龈炎指数。应用统计分析来评估牙龈增生与其他研究变量之间的关系，并检验年龄、性别、时间和移植类型的影响。43%的患者出现了牙龈增生。在研究期间，牙龈增生显著增加，而在接受口腔卫生培训和激励计划后，菌斑和牙龈炎显著减少。这项研究的结果表明，影响牙龈增生的基本因素是环孢素血药浓度，其次是菌斑/牙龈炎水平。移植类型和年龄组之间观察到的显著差异可能归因于环孢素浓度的差异。建议在移植手术前开展口腔卫生计划。
