Thomason J M, Kelly P J, Seymour R A
Department of Restorative Dentistry, University of Newcastle, Newcastle-upon-Tyne, UK.
J Clin Periodontol. 1996 Apr;23(4):367-71. doi: 10.1111/j.1600-051x.1996.tb00559.x.
The distribution of gingival overgrowth was investigated in a cohort of organ transplant patients, who were medicated with cyclosporin or the combination of cyclosporin and a calcium channel blocking drug. Gingival overgrowth scores were significantly higher at buccal sites than lingual-palatally (p < 0.0001). There was no significant difference between upper and lower overgrowth scores (p = 0.88). The most severe overgrowth was seen in the canine region. Overgrowth between the central incisors was significantly less than in the canine region (p > or = 0.044) and was similar to that in the molar and premolar region. Although raised overgrowth scores were associated with increased levels of plaque and gingival inflammation, the distribution could not be explained by this observation.
在一组接受环孢素或环孢素与钙通道阻滞剂联合用药的器官移植患者中，对牙龈过度生长的分布情况进行了调查。颊侧部位的牙龈过度生长评分显著高于舌腭侧（p < 0.0001）。上下牙龈过度生长评分之间无显著差异（p = 0.88）。最严重的过度生长出现在尖牙区。中切牙之间的过度生长明显少于尖牙区（p ≥ 0.044），且与磨牙和前磨牙区相似。尽管牙龈过度生长评分升高与菌斑和牙龈炎症水平增加有关，但这种分布情况无法用这一观察结果来解释。
