Somacarrera M L, Hernández G, Acero J, Moskow B S
Complutense University, Faculty of Dentistry, Department of Oral Medicine and Surgery, Madrid, Spain.
J Periodontol. 1994 Jul;65(7):666-70. doi: 10.1902/jop.1994.65.7.666.
This research was aimed at determining and comparing the pattern of localization of both cyclosporin-induced gingival overgrowth and associated periodontal variables in heart transplant patients. Thirty-nine patients undergoing cyclosporin treatment were studied for 6 months following transplant surgery. Oral hygiene and gingivitis were evaluated using the Silness-Löe and Löe-Silness indices. Gingival overgrowth was measured using a periodontal probe to determine the height of the gingiva at six points per tooth. Statistical hypothesis testing was applied to calculate the significance of the results. Overgrowth average showed a steady and significant growth. The graphs depicting average overgrowth localization, "standard periodontograms," showed remarkable symmetry, and a significantly anterior mandibular papillary distribution. No overgrowth was observed in edentulous areas. The localization of plaque and gingivitis followed a similar pattern; a highly significant correlation was found with the overgrowth localization pattern. It was concluded that the elimination of plaque is an important preventive measure for cyclosporin-induced gingival overgrowth, and that tooth or periodontium related factors have a significant impact on its pathogenesis.
本研究旨在确定并比较心脏移植患者中环孢素诱导的牙龈增生模式及相关牙周变量。对39例接受环孢素治疗的患者在移植手术后进行了6个月的研究。使用Silness-Löe指数和Löe-Silness指数评估口腔卫生和牙龈炎情况。使用牙周探针测量牙龈增生，以确定每颗牙齿六个点处牙龈的高度。应用统计假设检验来计算结果的显著性。增生平均值呈现出稳定且显著的增长。描绘平均增生定位的图表“标准牙周图”显示出显著的对称性，以及下颌前牙乳头分布显著。在无牙区未观察到增生。菌斑和牙龈炎的定位遵循相似模式；与增生定位模式存在高度显著的相关性。得出的结论是，消除菌斑是预防环孢素诱导的牙龈增生的重要措施，并且牙齿或牙周相关因素对其发病机制有显著影响。
