Effects of alpha-blocker on sperm concentration, motility, intraluminal pressure and fluid movement in the rat cauda epididymis.

PURPOSE

To investigate whether alpha blocker has an effect on epididymal sperm parameters, intraluminal pressure and fluid movement.

MATERIALS AND METHODS

Sprague-Dawley rats were given daily oral doses 1 mg./kg., 2 mg./kg., or 10 mg./kg. of Bunazosin, a selective alpha blocker, for 1 month. A micropuncture technique was used to collect intraluminal fluids.

RESULTS

Epididymal sperm concentrations were significantly increased. Progressive motility of spermatozoa was not altered. Intraluminal pressures were significantly reduced, and intraluminal fluid movement rates were significantly increased.

CONCLUSION

Alpha blocker has an effect on sperm transport and storage in the rat testis and epididymis.