Kawahito K, Kawakami M, Fujiwara T, Adachi H, Ino T
Department of Cardiovascular Surgery, Omiya Medical Center, Jichi Medical School, Saitama, Japan.
J Thorac Cardiovasc Surg. 1995 Jul;110(1):99-102. doi: 10.1016/S0022-5223(05)80014-5.
Cardiac operations with cardiopulmonary bypass cause a systemic inflammatory response. Neutrophils and monocytes-macrophages play an important role in triggering the initiation of the inflammatory response. Recently, some kinds of cytokines that are powerful leukocyte chemotactic factors have been characterized concerning an inflammatory response: interleukin-8 has a potent chemoattractant activity for neutrophils, and monocyte chemoattractant factor has monocyte-macrophage chemotactic activity. To investigate the possible roles of the cytokines in the inflammatory response in cardiopulmonary bypass, 12 adult patients undergoing cardiopulmonary bypass were studied for measurement of interleukin-8 and monocyte chemoattractant factor. Systemic blood was collected before cardiopulmonary bypass, at the end of cardiopulmonary bypass, and at 3, 12, 24, and 48 hours after cardiopulmonary bypass from the patients' radial arteries. Significant increases in levels of interleukin-8 and monocyte chemoattractant factor were detected with a peak level at 3 hours after bypass compared with levels before cardiopulmonary bypass (p < 0.05). This study demonstrated that interleukin-8 and monocyte chemoattractant factor are released into the circulation after adult hypothermic cardiopulmonary bypass and reach a maximum level 3 hours after bypass.
体外循环心脏手术会引发全身炎症反应。中性粒细胞和单核细胞 - 巨噬细胞在触发炎症反应的起始过程中起重要作用。最近，一些作为强大白细胞趋化因子的细胞因子在炎症反应方面已得到表征：白细胞介素 - 8对中性粒细胞具有强大的化学吸引活性，单核细胞趋化因子具有单核细胞 - 巨噬细胞趋化活性。为了研究这些细胞因子在体外循环炎症反应中的可能作用，对12例接受体外循环的成年患者进行了白细胞介素 - 8和单核细胞趋化因子的检测。在体外循环前、体外循环结束时以及体外循环后3、12、24和48小时从患者桡动脉采集全身血液。与体外循环前的水平相比，检测到白细胞介素 - 8和单核细胞趋化因子水平显著升高，在体外循环后3小时达到峰值水平（p < 0.05）。本研究表明，白细胞介素 - 8和单核细胞趋化因子在成人低温体外循环后释放到循环中，并在体外循环后3小时达到最高水平。
