Hongo K, Kobayashi S, Okudera H, Hokama M, Nakagawa F
Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.
Neurol Res. 1995 Apr;17(2):89-93. doi: 10.1080/01616412.1995.11740293.
To investigate the feasibility of a newly developed, near-infrared optical spectroscopy device, we analysed measurements of the infrared tracer indocyanine green (ICG) using sensors with a single near infrared light source and multiple light detectors. Two ml of ICG dye, 1.0 mg ml-1 in concentration, were injected into the internal carotid artery during cerebral angiography in 14 adult patients. The resultant washout curves were measured bilaterally using sensors with 4 detectors spaced at 10, 20, 30 and 40 mm from the infrared light source on the right side, and 15, 25, 35 and 45 mm from the source for the left side, respectively. Washout curves were analysed to determine the relative amplitude of the ICG absorption signal and deduce each detector's penetration distance. When ICG was injected into the internal carotid artery, relative absorption increased with detector distance from the light source. No substantial difference in attenuation was observed in any of the detectors during external carotid injection of ICG. The resultant information related depth of penetration of the light with source-detector separation distances. The feasibility of the system for measuring cerebral oxygen saturation and haemodynamics noninvasively or monitoring at bedside is discussed.
为了研究一种新开发的近红外光学光谱设备的可行性，我们使用具有单个近红外光源和多个光探测器的传感器，分析了红外示踪剂吲哚菁绿（ICG）的测量结果。在14例成年患者的脑血管造影过程中，将2 ml浓度为1.0 mg/ml的ICG染料注入颈内动脉。使用传感器双侧测量所得的洗脱曲线，右侧的4个探测器距红外光源的距离分别为10、20、30和40 mm，左侧的探测器距光源的距离分别为15、25、35和45 mm。分析洗脱曲线以确定ICG吸收信号的相对幅度，并推断每个探测器的穿透深度。当将ICG注入颈内动脉时，相对吸收随探测器与光源距离的增加而增加。在颈外动脉注射ICG期间，未在任何探测器中观察到衰减的实质性差异。所得信息与光源 - 探测器分离距离下光的穿透深度有关。讨论了该系统用于无创测量脑氧饱和度和血流动力学或床边监测的可行性。
