Faller G, Steininger H, Eck M, Hensen J, Hann E G, Kirchner T
Institute of Pathology, University of Erlangen-Nürnberg,Germany.
Virchows Arch. 1996 Feb;427(5):483-6. doi: 10.1007/BF00199508.
Colonization of human gastric mucosa with Helicobacter pylori leads to chronic active gastritis and induces the occurrence of an acquired mucosa-associated lymphoid tissue (MALT) in the stomach. This remodelling of the gastric mucosa together with chronic antigen persistence may induce autoimmune reactions. The aim of this study was to investigate humoral autoimmune reactions to human gastric mucosa in H. pylori gastritis and their clinical relevance. Sera from patients with dyspeptic symptoms were tested for presence of IgG immunoglobulins against H. pylori. Gastric infection with H. pylori and alterations of gastric mucosa were demonstrated by histological examination of gastric biopsy specimens. All sera were tested for reactivity against human gastric mucosa by immunohistochemistry. Two different in-situ binding sites of antigastric autoantibodies were observed. Binding to canalicular structures within parietal cells was significantly correlated with antibodies to H. pylori, elevated basal gastrin levels and atrophy of gastric corpus glands. Our data indicate that autoimmune reactions to antigens in the human gastric mucosa occur in H. pylori gastritis and that they may play a role in the pathogenesis of the disease.
幽门螺杆菌在人胃黏膜定植会导致慢性活动性胃炎，并诱发胃中获得性黏膜相关淋巴组织（MALT）的出现。胃黏膜的这种重塑以及慢性抗原持续存在可能会诱发自身免疫反应。本研究的目的是调查幽门螺杆菌胃炎中针对人胃黏膜的体液自身免疫反应及其临床相关性。检测有消化不良症状患者血清中抗幽门螺杆菌IgG免疫球蛋白的存在情况。通过胃活检标本的组织学检查证实胃感染幽门螺杆菌及胃黏膜改变。通过免疫组织化学检测所有血清与人胃黏膜的反应性。观察到抗胃自身抗体的两个不同原位结合位点。与壁细胞内小管状结构的结合与抗幽门螺杆菌抗体、基础胃泌素水平升高及胃体腺萎缩显著相关。我们的数据表明，幽门螺杆菌胃炎中存在针对人胃黏膜抗原的自身免疫反应，且它们可能在该疾病的发病机制中起作用。
