Haruma K, Kawaguchi H, Yoshihara M, Okamoto S, Sumii K, Kishimoto S, Kajiyama G
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
J Clin Gastroenterol. 1994 Jul;19(1):20-2. doi: 10.1097/00004836-199407000-00006.
We studied the relationship between Helicobacter pylori (H. pylori) infection and gastric acid secretion, along with fasting serum gastrin levels, in 55 asymptomatic healthy volunteers under 30 years old (29 H. pylori-positive, 26 H. pylori-negative). Mean scores of antral gastritis were significantly higher in H. pylori-positive subjects than in H. pylori-negative subjects. There was no significant difference in both basal and maximal acid output between H. pylori-positive and H. pylori-negative subjects. Fasting serum gastrin levels were significantly higher in H. pylori-positive subjects than in H. pylori-negative subjects. Sex did not significantly affect gastritis scores, gastric acid secretion, or fasting serum gastrin levels, although maximal acid output was slightly higher in H. pylori-negative men than in H. pylori-positive men. Our results suggest that H. pylori infection has no direct effect on gastric acid secretion in young healthy subjects, although it induces hypergastrinemia.
我们研究了55名30岁以下无症状健康志愿者（29名幽门螺杆菌阳性，26名幽门螺杆菌阴性）的幽门螺杆菌（H. pylori）感染与胃酸分泌以及空腹血清胃泌素水平之间的关系。幽门螺杆菌阳性受试者的胃窦炎平均评分显著高于幽门螺杆菌阴性受试者。幽门螺杆菌阳性和阴性受试者的基础胃酸分泌量和最大胃酸分泌量均无显著差异。幽门螺杆菌阳性受试者的空腹血清胃泌素水平显著高于幽门螺杆菌阴性受试者。性别对胃炎评分、胃酸分泌或空腹血清胃泌素水平无显著影响，尽管幽门螺杆菌阴性男性的最大胃酸分泌量略高于幽门螺杆菌阳性男性。我们的结果表明，幽门螺杆菌感染对年轻健康受试者的胃酸分泌没有直接影响，尽管它会诱发高胃泌素血症。
