甲醛胍诱导的雏鸡形觉剥夺性近视抑制伴随着脉络膜变薄，而视网膜功能得以保留。

Formoguanamine-induced inhibition of deprivation myopia in chick is accompanied by choroidal thinning while retinal function is retained.

作者信息

Westbrook A M, Crewther S G, Liang H, Beresford J A, Allen M, Keller I, Crewther D P

机构信息

School of Optometry, University of New South Wales, Kensington, Australia.

出版信息

Vision Res. 1995 Jul;35(14):2075-88. doi: 10.1016/0042-6989(94)00282-q.

DOI:10.1016/0042-6989(94)00282-q

PMID:7660611

Abstract

Twenty hatchling chickens were injected intravitreally every 4 days from day 2 to day 16 with dimethyl sulphoxide (DS) in one eye and DS or formoguanamine dissolved in DS (FG.DS) with or without occlusion in the other (FG.DS.MD, DS.MD, FG.DS). At day 16, the FG.DS.MD eyes failed to show the high refractive myopia and showed less axial elongation than that developed by the DS.MD eyes. Electroretinograms indicated that at the dosage used, FG.DS does not eliminate phototransduction. Light microscopy showed choroidal and retinal thinning in DS.MD and FG.DS.MD eyes but less than in FG.DS eyes, suggesting that change in choroidal thickness is unlikely to be the primary cause of form deprivation myopia.

摘要

从第2天到第16天，每隔4天给20只刚孵出的小鸡的一只眼睛玻璃体内注射二甲基亚砜（DS），另一只眼睛玻璃体内注射溶解于DS的甲脒胍（FG.DS），其中部分伴有遮盖（FG.DS.MD、DS.MD、FG.DS）。在第16天，FG.DS.MD组的眼睛未出现高度屈光性近视，其眼轴伸长程度低于DS.MD组的眼睛。视网膜电图表明，在所使用的剂量下，FG.DS不会消除光转导。光学显微镜检查显示，DS.MD组和FG.DS.MD组的眼睛脉络膜和视网膜变薄，但比FG.DS组的眼睛轻，这表明脉络膜厚度的变化不太可能是形觉剥夺性近视的主要原因。