Fargas-Babjak A, Forrest J B
Can Anaesth Soc J. 1979 Jan;26(1):6-14. doi: 10.1007/BF03039446.
The pulmonary vascular response to alveolar hypoxia with and without halothane exposure was measured in dogs. Hypoxia increased pulmonary artery pressure (Ppa) and pulmonary vascular resistance (PVR) so that in each case inverse linear relationships were found with arterial oxygen saturation. These responses were highly significant and reproduceable but varied greatly between individuals. Halothane administration resulted in an increased slope of PVR against oxygen saturation due to the fact that reduction in cardiac output exceeded the reduction in Ppa. An analysis of variance showed that it was possible to predict accurately the hypoxic PVR and Ppa responses under halothane anaesthesia from the control hypoxic responses. Animals with low PVR responses showed the greatest arterial oxygen desaturation with hypoxia, whereas high responders showed least oxygen desaturation. Thus it was possible to predict those individuals at risk from severe arterial oxygen desaturation under halothane anaesthesia.
在犬类动物中测量了有和没有氟烷暴露情况下肺血管对肺泡低氧的反应。低氧会增加肺动脉压（Ppa）和肺血管阻力（PVR），因此在每种情况下都发现与动脉血氧饱和度呈反向线性关系。这些反应具有高度显著性且可重复，但个体之间差异很大。由于心输出量的降低超过了Ppa的降低，氟烷给药导致PVR相对于血氧饱和度的斜率增加。方差分析表明，根据对照低氧反应可以准确预测氟烷麻醉下的低氧PVR和Ppa反应。PVR反应低的动物在低氧时动脉血氧饱和度下降最大，而反应高的动物血氧饱和度下降最少。因此，可以预测哪些个体在氟烷麻醉下有发生严重动脉血氧饱和度下降的风险。
