Carney B I, Jones K L, Horowitz M, Sun W M, Penagini R, Meyer J H
Department of Medicine, Royal Adelaide Hospital, South Australia.
Am J Physiol. 1995 Jun;268(6 Pt 1):G925-32. doi: 10.1152/ajpgi.1995.268.6.G925.
The aims of this study were to evaluate the effects of posture on gastric emptying, intragastric distribution, and satiation after a meal containing oil and aqueous phases in patients with exocrine pancreatic insufficiency. Five patients with cystic fibrosis (CF) consumed 60 ml 99mTc-labeled (V)-thiocyanate olive oil and 290 ml 113mIn-labeled diethylenetriaminepentaacetic acid soup while sitting and while lying in the left lateral decubitus position. Hunger and fullness before and after the meal were recorded. Results were compared with those obtained in 11 normal volunteers. In both postures emptying of oil was faster (P < 0.01) in CF patients. Emptying of the aqueous phase was faster (P < 0.01) in CF patients in the decubitus position. In normal subjects there was no overall difference in emptying of oil between the two postures, whereas emptying of the aqueous phase was delayed (P < 0.01) in the decubitus position. In CF patients emptying of oil was faster (P < 0.01) in the decubitus position, and emptying of the aqueous phase was only slightly faster (P < 0.05) in the sitting position. For both postures there was greater retention (P < 0.05) of oil in the proximal stomach in normal subjects than CF patients. Hunger decreased (P < 0.05) after the meal in the control subjects, but there was no change in CF patients. These results indicate that in CF patients with pancreatic exocrine insufficiency 1) gastric emptying of nonhomogenized fat is faster than normal, 2) gravity affects gastric emptying of oil, and 3) effects of a fatty meal on hunger are reduced.
本研究旨在评估姿势对外分泌性胰腺功能不全患者进食含油相和水相的餐后胃排空、胃内分布及饱腹感的影响。五名囊性纤维化（CF）患者在坐位和左侧卧位时分别摄入60 ml 99mTc标记的（V）-硫氰酸盐橄榄油和290 ml 113mIn标记的二乙三胺五乙酸汤。记录进餐前后的饥饿感和饱腹感。将结果与11名正常志愿者的结果进行比较。在两种姿势下，CF患者的油相排空均更快（P<0.01）。在卧位时，CF患者的水相排空更快（P<0.01）。在正常受试者中，两种姿势下油相排空无总体差异，而卧位时水相排空延迟（P<0.01）。在CF患者中，卧位时油相排空更快（P<0.01），坐位时水相排空仅略快（P<0.05）。对于两种姿势，正常受试者近端胃中油的潴留量均高于CF患者（P<0.05）。对照组受试者餐后饥饿感降低（P<0.05），但CF患者无变化。这些结果表明，对于患有胰腺外分泌功能不全的CF患者，1）非均质化脂肪的胃排空比正常情况更快，2）重力影响油的胃排空，3）脂肪餐对饥饿的影响减弱。
