England D M, Hochholzer L
Department of Pathology, Meriter Hospital, Madison, WI 53715, USA.
Am J Surg Pathol. 1995 Aug;19(8):887-99. doi: 10.1097/00000478-199508000-00003.
Mucous gland adenoma of the bronchus (MGAB) is a rare, solitary, benign, well-circumscribed, multicystic, predominately exophytic bronchial tumor. Mucous gland adenoma arises from the submucosal seromucous glands and ducts of proximal airways; since the location, signs and symptoms, and bronchoscopic findings are similar to those of other tumors arising in the bronchus, diagnosis depends on tissue biopsy. We herein report 10 patients with MGAB. Patients ranged in age from 25 to 67 years old (mean, 52). In two thirds of patients, the tumor was located in the middle or lower lobes. Tumors ranged in size from 0.8 to 6.8 cm (mean, 1.8). Cut surface was shiny, mucoid, cystic, and usually firm. Mucous gland adenomas are protean in their histologic patterns. They may appear glandular and tubulocystic or papillocystic, and they often show a mixture of these features. The tumors are rich in mucins and are immunopositive for epithelial markers. Mucous gland adenoma needs to be distinguished from low-grade malignant tumors of the bronchus--most notably, low-grade mucoepidermoid carcinoma. Complete removal of the tumor is curative.
支气管黏液性腺瘤（MGAB）是一种罕见的、孤立的、良性的、边界清楚的、多囊性的、主要为外生性的支气管肿瘤。黏液性腺瘤起源于近端气道的黏膜下浆液黏液腺和导管；由于其位置、体征和症状以及支气管镜检查结果与支气管内发生的其他肿瘤相似，诊断依赖于组织活检。我们在此报告10例支气管黏液性腺瘤患者。患者年龄在25至67岁之间（平均52岁）。三分之二的患者肿瘤位于中叶或下叶。肿瘤大小在0.8至6.8厘米之间（平均1.8厘米）。切面有光泽、呈黏液样、囊性，通常质地坚实。黏液性腺瘤的组织学形态多样。它们可能呈腺管状和微囊状或乳头状囊状，并且常常表现出这些特征的混合。肿瘤富含黏蛋白，上皮标志物免疫阳性。黏液性腺瘤需要与支气管低度恶性肿瘤相鉴别——最主要的是低度黏液表皮样癌。完整切除肿瘤可治愈。
