Zhang Xue-Ting, Yang Man, Liu Xiao-Fang, Lin Xu-Yong
Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
Medicine (Baltimore). 2018 Jan;97(3):e9597. doi: 10.1097/MD.0000000000009597.
Mucous gland adenoma is an extremely rare benign tumor predominately presented in central bronchus. Thus far, only six cases located in the periphery have been reported in English literature.
Herein, we report a case located in periphery of the lung with parenchymal involvement in a 59-year-old female. Histologically, the tumor appeared as peripheral lobulated and solid mass with the pushing border. The tumor was composed of abundant irregular glands, mucus-filled acini and tubules lined by bland cuboidal to columnar mucus-secreting epithelial cells lacking cellular atypia and mitotic activities. Moreover, the tumor contained fibromyxoid stroma with smooth muscular bundles and prominent lymph follicles, which has not been reported in previous cases.
Based on the morphological profile and immunohistochemical staining, the tumor was diagnosed as a mucous gland adenoma.
The patient then underwent wedge resection in our hospital.
The patient was alive with no tumor recurrence or metastasis within 16 months of follow-up.
We report a peculiar case of mucous gland adenoma that occurred in the periphery of the lung and involved the parenchyma. The present case reported the smooth muscular bundles presenting in the stroma, which could broaden the histologic profile of the tumor.
黏液性腺瘤是一种极为罕见的良性肿瘤，主要出现在中央支气管。迄今为止，英文文献中仅报道过6例位于外周的病例。
在此，我们报告一例59岁女性，肿瘤位于肺外周并累及实质。组织学上，肿瘤表现为外周分叶状实性肿块，边界呈推挤状。肿瘤由大量不规则腺体、充满黏液的腺泡和由温和的立方状至柱状黏液分泌上皮细胞衬里的小管组成，缺乏细胞异型性和有丝分裂活性。此外，肿瘤含有纤维黏液样间质，伴有平滑肌束和明显的淋巴滤泡，此前病例中未见报道。
根据形态学特征和免疫组化染色，该肿瘤被诊断为黏液性腺瘤。
患者随后在我院接受了楔形切除术。
患者存活，随访16个月内无肿瘤复发或转移。
我们报告了一例发生在肺外周并累及实质的特殊黏液性腺瘤病例。本病例报告了间质中出现的平滑肌束，这可能拓宽了该肿瘤的组织学特征。
