Shaunak S, Orrell R W, O'Sullivan E, Hawken M B, Lane R J, Henderson L, Kennard C
Academic Unit of Neuroscience, Charing Cross and Westminster Medical School, London, UK.
Ann Neurol. 1995 Jul;38(1):38-44. doi: 10.1002/ana.410380109.
Saccadic eye movements, fixation, and smooth pursuit were recorded in 17 subjects with amyotrophic lateral sclerosis (ALS) and 11 age-matched controls using a magnetic scleral search coil. Reflexive, remembered and antisaccades, and smooth pursuit at four target velocities were studied. Subjects with ALS showed significantly elevated error rates (distractibility) and latency in the antisaccade and remembered saccade paradigms but no abnormality of reflexive saccades. The frequency of small saccades that intruded on steady fixation (square-wave jerks) was also increased in ALS subjects. Peak velocity gain of smooth pursuit and performance on the Wisconsin Card Sort Test did not differ significantly between the two groups. These findings are consistent with prefrontal dysfunction in ALS and provide an independent source of support for the thesis that the pathology of this condition invades frontal cortex.
使用磁性巩膜搜索线圈记录了17例肌萎缩侧索硬化症（ALS）患者和11名年龄匹配的对照者的眼球扫视运动、注视和平稳跟踪。研究了反射性、记忆性和反扫视运动以及四种目标速度下的平稳跟踪。ALS患者在反扫视和记忆性扫视范式中表现出显著升高的错误率（注意力分散）和潜伏期，但反射性扫视无异常。侵入稳定注视（方波急跳）的小扫视频率在ALS患者中也增加。两组之间平稳跟踪的峰值速度增益和威斯康星卡片分类测验的表现无显著差异。这些发现与ALS患者的前额叶功能障碍一致，并为这种疾病的病理侵犯额叶皮层这一论点提供了独立的支持来源。
